Results 91 to 100 of about 8,028 (315)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Generalization of Runoff Risk Prediction at Field Scales to a Continental‐Scale Region Using Cluster Analysis and Hybrid Modeling [PDF]

open access: bronze, 2022
Chanse Ford   +8 more
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

The p-Laplace equation in a class of Hormander vector fields

open access: yesElectronic Journal of Differential Equations, 2019
We find the fundamental solution to the p-Laplace equation in a class of Hormander vector fields that generate neither a Carnot group nor a Grushin-type space. The singularity occurs at the sub-Riemannian points, which naturally corresponds to finding
Thomas Bieske, Robert D. Freeman
doaj  

Nonlinear q-Generalizations of Quantum Equations: Homogeneous and Nonhomogeneous Cases—An Overview

open access: yesEntropy, 2017
Recent developments on the generalizations of two important equations of quantum physics, namely the Schroedinger and Klein–Gordon equations, are reviewed. These generalizations present nonlinear terms, characterized by exponents depending on an index q,
Fernando D. Nobre   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Two-spinor description of massive particles and relativistic spin projection operators

open access: yesNuclear Physics B, 2018
On the basis of the Wigner unitary representations of the covering group ISL(2,C) of the Poincaré group, we obtain spin-tensor wave functions of free massive particles with arbitrary spin.
A.P. Isaev, M.A. Podoinitsyn
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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