Results 71 to 80 of about 311,144 (289)

Efficient semiparametric estimation in generalized partially linear additive models for longitudinal/clustered data

, 2014
We consider efficient estimation of the Euclidean parameters in a generalized partially linear additive models for longitudinal/clustered data when multiple covariates need to be modeled nonparametrically, and propose an estimation procedure based on a ...
Cheng, Guang, Huang, Jianhua Z., Zhou, Lan   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Generalized Additive Model for Predicting ECBR of Stabilized Subgrades for Pavement

IEEE Access
This study presents a Generalized Additive Model (GAM) to predict the effective CBR (ECBR) of soil subgrade stabilized with recycled plastic waste under repeated loading (RL) conditions.
Alka Shah, Tejaskumar Thaker, Vipin Shukla   +2 more
doaj   +1 more source

A Generalized Additive Model Combining Principal Component Analysis for PM2.5 Concentration Estimation

ISPRS International Journal of Geo-Information, 2017
As an extension of the traditional Land Use Regression (LUR) modelling, the generalized additive model (GAM) was developed in recent years to explore the non-linear relationships between PM2.5 concentrations and the factors impacting it.
Shuang Li, Liang Zhai, Bin Zou, Huiyong Sang, Xin Fang   +4 more
doaj   +1 more source

On the decomposition of Generalized Additive Independence models

, 2015
The GAI (Generalized Additive Independence) model proposed by Fishburn is a generalization of the additive utility model, which need not satisfy mutual preferential independence. Its great generality makes however its application and study difficult.
Grabisch, Michel, Labreuche, Christophe
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Evaluation of oriental beech (Fagus orientalis L.) site productivity using generalized additive model (Case study: Tarbiat Modares University Forest Research Station) [PDF]

مجله جنگل ایران, 2015
Site productivity is a key indicator of forest ecosystem; therefore it is an important criterion for forest manager for estimating the yield, annual exploitation and growth, and choosing the most suitable tree species for sites as well.
doaj  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Association between the metabolic score for insulin resistance and prostate cancer: a cross-sectional study in Xinjiang [PDF]

PeerJ
Background Insulin resistance is associated with the development and progression of various cancers. However, the epidemiological evidence for the association between insulin resistance and prostate cancer is still limited.
Jinru Wang, Aireti Apizi, Ning Tao, Hengqing An   +3 more
doaj   +2 more sources