Results 61 to 70 of about 7,637,186 (260)

Generalized Monotonic Regression Based on B-Splines with an Application to Air Pollution Data [PDF]

, 2005
In many studies where it is known that one or more of the certain covariates have monotonic effect on the response variable, common fitting methods for generalized additive models (GAM) may be affected by a sparse design and often generate implausible ...
Leitenstorfer, Florian, Tutz, Gerhard
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Optimal design for additive partially nonlinear models [PDF]

, 2010
We develop optimal design theory for additive partially nonlinear regression models, showing that Bayesian and standardized maximin D-optimal designs can be found as the products of the corresponding optimal designs in one dimension.
D. C. Woods, Dette, H., Woods, D. C., Dette, Holger, H. Dette, Woods, David C., Biedermann, S., Woods, D.C., S. Biedermann, Biedermann, Stefanie   +9 more
core   +1 more source

Analyzing weight evolution in mice infected by Trypanosoma cruzi

Acta Scientiarum. Health Sciences, 2020
Concerning the specificities of a longitudinal study, the trajectories of a subject's mean responses not always present a linear behavior, which calls for tools that take into account the non-linearity of individual trajectories and that describe them ...
Breno Gabriel da Silva, Terezinha Aparecida Guedes, Vanderly Janeiro, Érika Cristina Ferreira, Silvana Marques de Araújo, Larissa Ciupa   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Appraisal Using Generalized Additive Models [PDF]

Many of the results from real estate empirical studies depend upon using a correct functional form for their validity. Unfortunately, common parametric statistical tools cannot easily control for the possibility of misspecification.
R. Kelley Pace
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Modeling the short-term effect of traffic on air pollution in Torino with generalized additive models [PDF]

Vehicular traffic typically plays an important role in atmospheric pollution. This is especially true in urban areas, where high pollutant concentrations are often observed. In this paper, we consider hourly measures of concentrations of nitrogen oxides (
Rosalba Ignaccolo, Vanja Dukic, Pancrazio Bertaccini   +2 more
core