Results 81 to 90 of about 7,637,186 (260)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Generalized Additive Modelling of Mixed Distribution Markov Models with Application to Melbourne's Rainfall. [PDF]
We consider modelling time series using a generalized additive model with first- order Markov structure and mixed transition density having a discrete component at zero and a continuous component with positive sample space.
Hyndman, R.J., Grunwald, G.K.
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FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Structured additive regression for multicategorical space-time data: A mixed model approach [PDF]
, 2004 In many practical situations, simple regression models suffer from the fact that the dependence of responses on covariates can not be sufficiently described by a purely parametric predictor.
Kneib, Thomas, Fahrmeir, Ludwig
core +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Generalized boosted additive models
, 2012 The doctoral thesis is focused on non-parametric nonlinear regression and additive modeling. Regression analysis is a central method of statistical data analysis. Linear regression concerns the conditional distribution of a dependent variable, Y , as a
D'AMBROSIO, ANTONIO
core
Curved Text Line Rectification via Bresenham’s Algorithm and Generalized Additive Models
SignalsThis paper presents a methodology for rectifying curved text lines, a crucial process in optical character recognition (OCR) and computer vision. Utilizing generalized additive models (GAMs), the proposed method accurately estimates text curvature and ...
Thomas Stogiannopoulos +1 more
doaj +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
An Algorithm for Clustered Data Generalized Additive Modelling with S-PLUS [PDF]
We present a set of functions in S-PLUS to implement the clustered data generalized additive marginal modelling (CDGAM) strategy proposed by Berhane and Tibshirani (1998).
Vincent Carey, Lin Yee Hin
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