Results 61 to 70 of about 961,498 (296)

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Complex Pythagorean Normal Interval-Valued Fuzzy Aggregation Operators for Solving Medical Diagnosis Problem

International Journal of Computational Intelligence Systems
This paper presents a new methodology for solving multiple-attribute decision-making problems (MADMs) using a complex Pythagorean normal interval-valued fuzzy set (CPNIVFS), which is an extended concept of a complex Pythagorean fuzzy set.
Murugan Palanikumar, Nasreen Kausar, Dragan Pamucar, Salma Khan, Mohd Asif Shah   +4 more
doaj   +1 more source

New Pythagorean Fuzzy Interaction Maclaurin Symmetric Mean Operators and Their Application in Multiple Attribute Decision Making

IEEE Access, 2018
The aim of this paper is to develop some Pythagorean fuzzy interaction operators by considering interaction between membership and non-membership. The generalized Pythagorean fuzzy interaction weighted averaging operator and the generalized Pythagorean ...
Wei Yang, Yongfeng Pang
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Decision making by the values of generalized average fuzzy functions

Lietuvos Matematikos Rinkinys, 2012
Notions of point, interval and triangular intuitionistic fuzzy numbers are introduced. The generalized weighted averaging operator is used for solving multiple criteria decision making problems.
Natalja Kosareva, Aleksandras Krylovas
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Bayesian curve estimation by model averaging [PDF]

, 2003
A bayesian approach is used to estimate a nonparametric regression model. The main features of the procedure are, first, the functional form of the curve is approximated by a mixture of local polynomials by Bayesian Model Averaging (BMA); second, the ...
Peña, Daniel, Redondas, María Dolores
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Model averaging estimation of generalized linear models with imputed covariates [PDF]

, 2015
We address the problem of estimating generalized linear models when some covariate values are missing but imputations are available to fill-in the missing values.
Peracchi, F, DARDANONI, Valentino, Peracchi, F., PERACCHI, FRANCO, DE LUCA, Giuseppe, Modica, S, De Luca, G, Dardanoni, V, MODICA, Salvatore   +8 more
core   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source