Results 71 to 80 of about 2,745 (257)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Expanding the therapeutic horizons of spesolimab: a review of off-label applications for inflammatory skin diseases

Journal of Dermatological Treatment
Purpose This review aims to outline the crucial role of IL-36 signaling in inflammatory skin diseases and summarize the therapeutic potential of spesolimab.
Hanlin Zhang, Jia Zhou, Keyun Tang, Xinyi Zhang, Hongzhong Jin   +4 more
doaj   +1 more source

Chronic kidney disease in liver transplantation: Evaluation of kidney function

Revista de Gastroenterología de México (English Edition), 2019
Chronic kidney disease is one of the main comorbidities affecting liver transplant recipients. Most of those patients have some degree of acute or chronic kidney dysfunction at the time of transplantation, moreover they can also develop de novo chronic ...
A. Meraz-Muñoz, I. García-Juárez
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Shear Correction Factor for Porous Eco-Materials: Mechanical Characterization of a Heterogeneous Medium

Buildings
Classical formulas for the shear correction factor ks, typically derived for homogeneous continua, are unsuitable for porous media exhibiting local density gradients, irregular pore morphologies, and spatially varying stiffness.
Julia Graczyk, Tomasz Gajewski, Tomasz Garbowski   +2 more
doaj   +1 more source

Enfermedad renal crónica en el trasplante hepático: evaluación de la función renal

Revista de Gastroenterología de México, 2019
Resumen: La enfermedad renal crónica (ERC) es una de las principales comorbilidades que afectan a los pacientes receptores de trasplante hepático.
A. Meraz-Muñoz, I. García-Juárez
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

GCS y desempeño en empresas proveedoras de primer nivel de una ensambladora automotriz

Ciencias Administrativas Teoría y Praxis, 2018
SCM and performance in tier 1 suppliers of an auto Original Equipment Manufacturer Resumen  El estudio examina el impacto de la gestión de la cadena de suministro sobre el desempeño competitivo de empresas de diferentes países, que son proveedoras
Jorge Alberto Rodríguez-Steffani, Carmen Estela Carlos-Ornelas   +1 more
doaj