Results 1 to 10 of about 1,889 (122)

Case Report: Successful management of refractory palmoplantar pustulosis with upadacitinib [PDF]

Frontiers in Immunology
Palmoplantar Pustulosis (PPP) is a rare chronic skin disorder characterized by recurrent sterile pustules on palms and soles, leading to significant pain and functional impairment. Treatments include topical medications, phototherapy, systemic treatments,
Boyun Yang, Hanxiao Yu, Wo Yao, Huiying Wang   +3 more
exaly   +4 more sources

Differentiation of Palmoplantar Psoriasis, Palmoplantar Pustulosis and Hyperkeratotic Palmoplantar Eczema Using Proteomic Analysis of Tape Strip Samples. [PDF]

Exp Dermatol
Tape strip‐based targeted proteomics reveals specific protein patterns in PPP compared with PP and HPE. The findings demonstrate the feasibility of tape strip proteomics to differentiate PPP from PP and HPE. ABSTRACT Palmoplantar inflammatory dermatoses, including hyperkeratotic palmoplantar eczema (HPE), palmoplantar psoriasis (PP) and palmoplantar ...
Johansen MB, Altintas S, Bronze M, Woetmann A, Zachariae C, Näslund-Koch C, Løvendorf MB, Skov L.   +7 more
europepmc   +2 more sources

Could the IL-17 cytokine family be a promising target for the treatment of palmoplantar pustulosis? [PDF]

J Eur Acad Dermatol Venereol
Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 5, Page 728-729, May 2026.
Mrowietz U, Gerdes S.
europepmc   +2 more sources

Apremilast in Japanese patients with palmoplantar pustulosis: A randomized, Phase 3 trial. [PDF]

J Eur Acad Dermatol Venereol
In this Phase 3 trial of Japanese patients with moderate to severe PPP (NCT05174065), significantly more patients achieved PPPASI‐50 at Week 16 with apremilast versus placebo. Patient‐reported outcomes, including pruritus and pain/discomfort, also showed significantly greater decreases at Week 16 with apremilast versus placebo.
Terui T, Okubo Y, Kobayashi S, Morita A, Imafuku S, Tada Y, Abe M, Strober B, Gooderham M, Zhang W, Shimauchi J, Yaguchi M, Kimura T, Ogawa R, Amouzadeh H, Murakami M.   +15 more
europepmc   +2 more sources

The Relative Efficacy of Monotherapies for Palmoplantar Pustulosis and Palmoplantar Psoriasis: A Network Meta-Analysis Study of the Palmoplantar Spectrum [PDF]

Medicina
Background and Objectives: Palmoplantar pustulosis (PPPust) and palmoplantar psoriasis (PPso) are distinct palm/sole dermatoses that have historically shared the abbreviation “PPP”. Though the two—since the advent of advanced biotechnology—are now deemed
Aditya K. Gupta, Mary A. Bamimore, Tong Wang, Tina Bhutani, Vincent Piguet, Mesbah Talukder   +5 more
doaj   +2 more sources

Efficacy and safety of brodalumab in palmoplantar pustulosis: A 68-week randomized Phase 3 trial. [PDF]

J Eur Acad Dermatol Venereol
This open‐label study is a continuation of the 16‐week double‐blind, Phase 3 trial assessing the efficacy and safety of brodalumab 210 mg subcutaneously, till a 68‐week extension period. Continued improvement was seen in the PPPASI 50/75/90 responses, PPPSI scores, PGA 0/1 responses and DLQI. Abstract Background The efficacy and safety of brodalumab in
Murakami M, Okubo Y, Kobayashi S, Kikuta N, Ouchi Y, Shishido K, Terui T.   +6 more
europepmc   +2 more sources

Janus Kinase Inhibitors for Treatment of Palmoplantar Pustulosis, Generalized Pustular Psoriasis, and Palmoplantar Pustular Psoriasis: A Systematic Review of the Literature. [PDF]

Health Sci Rep
ABSTRACT Introduction Palmoplantar pustulosis (PPP) is a chronic, recurrent, inflammatory disease and assumed to be a subtype of psoriasis. Pustular psoriasis (PP) is a chronic inflammatory disease that is further subclassified into various entities with different presentations including generalized pustular psoriasis (GPP) and palmoplantar pustular ...
Ansari MS, Heidari S, Pourgholi E, Bahramian S, Tootoonchi N, Vahabi SM.   +5 more
europepmc   +2 more sources

Case Report: Successful treatment of refractory synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome and palmoplantar pustulosis with ustekinumab [PDF]

Frontiers in Immunology
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disease mainly manifested as skin and osteoarticular lesions.
Luxia Chen, Qichang Liang, Sijia Chen, Hao Cheng   +3 more
doaj   +2 more sources

Extra-Palmoplantar Lesions of Palmoplantar Pustulosis: Underrecognized but Important Manifestation [PDF]

Indian Journal of Dermatology
Background: Patients with palmoplantar pustulosis (PPP) rarely develop scaly erythematous and/or pustular lesions on sites other than the palms and soles, such as the dorsa of the feet, lower legs, knees, elbows, buttocks and trunk.
Toshiyuki Yamamoto
doaj   +2 more sources

Successful treatment of refractory palmoplantar pustulosis by upadacitinib: report of 28 patients

Frontiers in Medicine
BackgroundUpadacitinib, a specific JAK1 inhibitor, has minimal effect on other JAK subtypes. It influences the inflammatory process in various ways. Upadacitinib has been approved for conditions such as rheumatoid arthritis, psoriatic arthritis, atopic ...
Na Du, Jingyi Yang, Yiwen Zhang, Xinyan Lv, Lei Cao, Lei Cao, Lei Cao, Wei Min   +7 more
exaly   +3 more sources