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Upadacitinib in the treatment of SAPHO syndrome: a case report [PDF]

Frontiers in Immunology
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, a rare autoinflammatory disease, is usually defined by musculoskeletal symptoms and cutaneous manifestations.
Yanran Yang, Zhanxue Sun, Yongpeng Ge
doaj   +4 more sources

SAPHO Syndrome Presenting With Severe Inflammatory Back Pain (Sacroiliitis) and Rare Retinol Associated Myopathy in an Iraqi Adolescent Male: A Case Report and Literature Review [PDF]

Clinical Case Reports
SAPHO syndrome is a rare autoinflammatory disorder characterized by synovitis, acne, pustulosis, hyperostosis, and osteitis. Although musculoskeletal and dermatologic manifestations are well recognized, extra‐articular involvement remains uncommon ...
Farah Jaafar Mahdi, Ali Saad Al‐Shammari, Mustafa Majid Hameed, Marwah Sami Ahmed, Ibrahim Khalil, Zahraa Saeed Fahad, Ahmed Dahham Hasan, Nizar Abdulateef Jassim   +7 more
doaj   +3 more sources

The role of cytokines in the pathogenesis of SAPHO syndrome [PDF]

Frontiers in Immunology
SAPHO syndrome is a complex inflammatory disorder affecting the skin and bones, characterized by osteomyelitis, acne, and pustulosis. Cytokines play a pivotal role in the pathogenesis of SAPHO syndrome, especially in inflammatory responses and immune ...
Yi Yang, Yi Yang, Qianzhu Chen, Qianzhu Chen, Weiyang Zhong, Weiyang Zhong   +5 more
doaj   +4 more sources

Family aggregation and prevalence of other autoimmune diseases in SAPHO syndrome [PDF]

Heliyon, 2023
Objective: SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) syndrome is a heterogeneous disease that clinically manifests as chronic inflammatory osteoarticular and dermatological lesions.
Chen Li, Hesong Wang, Haixu Jiang, Yuming Shao, Guangrui Huang, Kai Yuan, Shufeng Wei   +6 more
doaj   +2 more sources

Evaluation of tonsillectomy in the treatment of SAPHO syndrome: past evidence and future directions [PDF]

Frontiers in Medicine
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare aseptic inflammatory clinical syndrome characterized by widespread skin lesions and bone-joint lesions.
Wen-Yuan Gan, Ben-Hong Ren, Qing-Ping Zhang, Yi Wang   +3 more
doaj   +2 more sources

Postpartum lumbopelvic pain could be SAPHO syndrome: a case report [PDF]

Frontiers in Immunology
BackgroundSynovitis–acne–pustulosis–hyperostosis–osteitis (SAPHO) syndrome is a rare autoimmune disorder. The involvement of spinal and sacroiliac joint in SAPHO syndrome closely resembles the manifestations of postpartum lumbopelvic pain (LPP).Case ...
Zheng Weiwei, Zhang Junhong, Zhang Rong
doaj   +2 more sources

Familial clustering of SAPHO syndrome. [PDF]

Cent Eur J Immunol
In a novel investigation of familial aggregation in SAPHO syndrome, a rare chronic autoinflammatory disorder characterized by the acronym synovitis, acne, pustulosis, hyperostosis, and osteitis, we identified a unique familial cohort with four affected individuals, including a male, marking the first report of male familial involvement in the ...
Gu M, Zheng Z, Zhang C, Zhang Y, Wu Y, Li C.   +5 more
europepmc   +4 more sources

Enteropathic SAPHO Syndrome in Ulcerative Colitis Responsive to Bisphosphonates [PDF]

Case Reports in Rheumatology
SAPHO syndrome, a rare inflammatory disorder of bone, joints, and skin, is named based on the presence of synovitis, acne, pustulosis, hyperostosis, and osteitis.
Jordan Phillipps, Sehreen Mumtaz, Jayesh Valecha, Rupert O. Stanborough, Florentina Berianu, Ejigayehu Abate, Vikas Majithia   +6 more
doaj   +2 more sources

Case Report: Successful treatment of SAPHO syndrome refractory to adalimumab with upadacitinib [PDF]

Frontiers in Immunology
BackgroundSynovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoinflammatory disorder characterized by osteoarticular and cutaneous manifestations.
Jinwan Du, Yeshan Li, Shaohui Geng, Chen Li, Shike Shang   +4 more
doaj   +2 more sources

Coexistence of SAPHO syndrome and IgG4‐related disease with Upadacitinib [PDF]

Clinical & Translational Immunology
Objectives To describe the first reported case of coexisting Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome and IgG4‐related disease (IgG4‐RD) and to evaluate the therapeutic response to Upadacitinib.
Hang Zhou, Xin Zhao, Ru Chen, Tianqi Wang, Yi Zhuang, Yanying Liu   +5 more
doaj   +2 more sources