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Therapeutic approaches for SAPHO syndrome from the perspective of pathogenesis: a review of the literature [PDF]

Frontiers in Immunology
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare autoinflammatory disease characterized by cutaneous manifestations and osteoarticular damage.
Yunuo Wang, Mengjiao Gu, Zixiang Zheng, Haixu Jiang, Luyao Han, Hanjing Huang, Yuanhao Wu, Chen Li, Chen Li   +8 more
doaj   +2 more sources

SAPHO syndrome

Rheumatology, 2021
Clinical History: A 51-year-old female presented with long-standing right upper abdominal pain, minimal weight loss (3 kg in 6 months), and slight night sweats. Laparoscopic cholecystectomy had not resolved the complaints. Except for diffuse hepatic steatosis, abdominal ultrasound was unremarkable. Apart from slightly elevated fibrinogen and liver
Peng Xu, Gaofeng Yi, Jun Li
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Awareness of the Risk of Paradoxical Psoriasis in Patients with SAPHO Syndrome Undergoing Treatment with Secukinumab: A Case Series [PDF]

Journal of Inflammation Research
Cheng Xu,* Xiayan Xu,* Yongmei Han Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongmei Han ...
Xu C, Xu X, Han Y
doaj   +2 more sources

Genome-Wide Association Identifies Risk Pathways for SAPHO Syndrome

Frontiers in Cell and Developmental Biology, 2021
SAPHO syndrome is a rare chronic inflammatory disease which is characterized by the comprehensive manifestations of bone, joint, and skin. However, little is known about the pathogenesis of SAPHO syndrome.
Ruikun Cai, Ruikun Cai, Yichao Dong, Yichao Dong, Mingxia Fang, Mingxia Fang, Yuxuan Fan, Yuxuan Fan, Zian Cheng, Zian Cheng, Yue Zhou, Yue Zhou, Jianen Gao, Jianen Gao, Feifei Han, Changlong Guo, Changlong Guo, Xu Ma, Xu Ma   +18 more
doaj   +1 more source

Clinical Images: Successfully treated mandibular osteomyelitis by tumor necrosis factor inhibitor in SAPHO syndrome. [PDF]

Arthritis Rheumatol
Arthritis &Rheumatology, Volume 78, Issue 4, Page 993-994, April 2026.
Oba S, Hosoya T, Yasuda S, Yokoyama K, Tomioka H, Harada H.   +5 more
europepmc   +2 more sources

Abundance alteration of nondominant species in fecal-associated microbiome of patients with SAPHO syndrome

BMC Microbiology, 2021
Background SAPHO syndrome is a group of symptoms consisting of synovitis, acne, pustulosis, hyperostosis and osteosis. There is no specific laboratory index assist in the diagnosis of SAPHO because of its highly heterogeneous clinical manifestations ...
Jianhua Zhen, Yuxiu Sun, Pengfei Zhao, Chen Li, Hesong Wang, Yini Li, Lu Zhao, Li Wang, Guangrui Huang, Anlong Xu   +9 more
doaj   +1 more source

SAPHO syndrome with enthesopathy [PDF]

BMJ Case Reports, 2019
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome was first described as chronic recurrent multifocal osteomyelitis. Because of its rarity, a thorough description of its clinical manifestations is lacking. Herein, we describe the clinical manifestations and imaging features, especially the enthesopathy in bilateral Achilles ...
Chin-Fang Su, Yu-Chuan Shen, Hsien-Tzung Liao, Chang-Youh Tsai   +3 more
openaire   +2 more sources

The value of multi-modality imaging in establishing the diagnosis of Adolescent SAPHO

Radiology Case Reports, 2022
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) is a rare chronic autoinflammatory disorder of unknown etiology. Radiological investigation, including the use of magnetic resonance imaging and nuclear medicine is pivotal to the ...
Sudarshan Ravi, BMed, MD, Abhishikta Dey, BMed, MD, FRACP, Damien McKay, MBBS, BAppSc (Physiotherapy) MSpMed Dip Paeds, FRACP, Praneal Sharma, MBBS, FRANZCR, Sugendran Pillay, MBBS (Hons.), BPharm, FRANZCR   +4 more
doaj   +1 more source

Transient hypercalcemia in a patient with SAPHO syndrome

Journal of General and Family Medicine, 2022
We here report a case of SAPHO (synovitis‐acne‐pustulosis‐hyperostosis‐osteitis) syndrome with hypercalcemia. The patient was diagnosed with SAPHO syndrome at the age of 54, because he exhibited osteitis and hyperostosis around the sternoclavicular ...
Tadashi Yoshida, Mototsugu Oya
doaj   +1 more source

Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome with Purely Osteolytic, Not Osteosclerotic, Lesions Mimicking a Malignant Tumor

Case Reports in Rheumatology, 2020
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare inflammatory disorder with multiple phenotypes. The syndrome has identifiable radiologic characteristics that are the most important when making a diagnosis.
Hideyuki Kinoshita, Takeshi Ishii, Hiroto Kamoda, Yoko Hagiwara, Toshinori Tsukanishi, Sumihisa Orita, Kazuhide Inage, Naoya Hirosawa, Seiji Ohtori, Tsukasa Yonemoto   +9 more
doaj   +1 more source