Results 71 to 80 of about 2,407,813 (254)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Study of socioeconomic differences of long-term PM2.5 exposure and population mortality risk - based on 345 cities from 2000 to 2019 in China

BMC Public Health
Background Previous studies have thoroughly evaluated the association between long-term exposure to PM2.5 and mortality, but the effect of socioeconomic status on the association remains controversial.
Surong Zhao, Xingyu Zhang, Ronghang Liu, Junyan Liu, Xiaoqian Shao, Wanru Zhao, Jiu Wang, Yang Zhao, Chunlei Han   +8 more
doaj   +1 more source

A numerical method of nonlinear estimation based on difference equations

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2018
The article considers a new numerical method for estimating the parameters of nonlinear mathematical models based on difference equations describing the results of observations.
Vladimir E Zoteev
doaj   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Analysis of neonatal clinical trials with twin births

BMC Medical Research Methodology, 2009
Background In neonatal trials of pre-term or low-birth-weight infants, twins may represent 10–20% of the study sample. Mixed-effects models and generalized estimating equations are common approaches for handling correlated continuous or binary data ...
Shaffer Michele L, Kunselman Allen R, Watterberg Kristi L   +2 more
doaj   +1 more source

Utility of the APE2 Score as a Diagnostic Tool for Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To retrospectively evaluate the diagnostic performance of the Antibody Prevalence in Epilepsy and Encephalopathy (APE2) score relative to clinician‐adjudicated autoimmune encephalitis (AE) and the Graus criteria in a tertiary neuroimmunology referral cohort, including antibody‐negative AE.
Bijoya Basu, Sophia F. Damman, Samhitha M. Rai, Hesham Abboud   +3 more
wiley   +1 more source

Generalized Estimating Equations Boosting (GEEB) machine for correlated data

Journal of Big Data
Rapid development in data science enables machine learning and artificial intelligence to be the most popular research tools across various disciplines. While numerous articles have shown decent predictive ability, little research has examined the impact
Yuan-Wey Wang, Hsin-Chou Yang, Yi-Hau Chen, Chao-Yu Guo   +3 more
doaj   +1 more source

Generalized single-index models: The EFM approach [PDF]

Generalized single-index models are natural extensions of linear models and circumvent the so-called curse of dimensionality. They are becoming increasingly popular in many scientific fields including biostatistics, medicine, economics and finan- cial ...
Xia Cui, Lixing Zhu, Wolfgang Karl Härdle   +2 more
core  

Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring

Annals of Clinical and Translational Neurology, EarlyView.
The early‐morning surge in false seizure alarms supports exploring time‐ or state‐dependent detection thresholds to reduce false detections. ABSTRACT Seizure detection devices can improve the safety of children with epilepsy, yet high false alarms limit their clinical applicability.
Mohammad Shahbakhti, Anemoon T. Bosch, Job van der Palen, Franciscus S. Leijten, Johannes P. van Dijk, Richard H. C. Lazeron, Roland D. Thijs   +6 more
wiley   +1 more source

A study on the correlations of PRL levels with anxiety, depression, sleep, and self-efficacy in patients with prolactinoma

Frontiers in Endocrinology
PurposeThe purpose of this study was to explore the factors influencing PRL levels in patients with prolactinoma and to investigate the correlations between anxiety, depression, sleep, self-efficacy, and PRL levels.MethodsThis retrospective study ...
Xiaoju Miao, Xiaoju Miao, Zhongmin Fu, Zhongmin Fu, Xian Luo, Xian Luo, Jun Wang, Jun Wang, Lili Yuan, Lili Yuan, Shunjun Zhao, Shunjun Zhao, Yi Feng, Shiming Huang, Shunwu Xiao   +14 more
doaj   +1 more source