Results 51 to 60 of about 57,784 (254)

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Effect of Reconstructive Surgery and Functional Brace Treatments on Kinesthesia in Patients with Acute Anterior Cruciate Ligament Tear

Journal of Rehabilitation, 2013
Objective: Anterior cruciate ligament (ACL) tear is one of the most common knee injuries. Kinesthesia after ACL tear is impaired. In this study, using hybrid generalized estimation equations (GEE) can be efficient method in analyzing correlated data, we ...
Shahram Ya'ghoubi, Masoud Karimlou, Roshanak Baghaei-Roudsari, Enayatollah Bakhshi   +3 more
doaj  

Longitudinal data methods for evaluating genome-by-epigenome interactions in families

BMC Genetics, 2018
Background Longitudinal measurement is commonly employed in health research and provides numerous benefits for understanding disease and trait progression over time. More broadly, it allows for proper treatment of correlated responses within clusters. We
Justin C. Strickland, I-Chen Chen, Chanung Wang, David W. Fardo   +3 more
doaj   +1 more source

Reperfusion‐Dependent Outcomes After Endovascular Thrombectomy Stratified by NIHSS‐ASPECTS Clinical‐Core Mismatch

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht, Lukas Meyer, Gabriel Broocks, Matthias Bechstein, Christian Thaler, Christian Heitkamp, Laurens Winkelmeier, Vincent Geest, Alexander Heitkamp, Maximilian Jungnitz, Gregor Peter, Luca Meucci, Tobias Faizy, Jawed Nawabi, Caspar Brekenfeld, Fabian Flottmann, Maximilian Schell, Alexandros Hadjilaou, Uta Hanning, Götz Thomalla, Jens Fiehler, Susanne Gellißen, Helge C. Kniep, for the German Stroke Registry Endovascular Treatment, (GSR‐ET) Alexander Nave, Anna Alegiani, Annerose Mengel, Arno Reich, Bernd Eckert, Charlotte Pietrock, Christian Nolte, Eberhard Siebert, Fabian Flottmann, Fee Keil, Franziska Dorn, Gabor Petzold, Götz Thomalla, Hanna Zimmermann, Jan Borggrefe, Jan Hendrik Schäfer, Jens Fiehler, Joachim Röther, Klaus Gröschel, Lars Kellert, Mario Abruscato, Maximilian Schell, Omid Nikoubashman, Peter Schellinger, Silke Wunderlich, Steffen Tiedt, Sven Thonke, Timo Uphaus, Tobias Boeckh‐Behrens, Ulrike Ernemann   +53 more
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Schauder Estimates for Equations Associated with Lévy Generators [PDF]

Integral Equations and Operator Theory, 2019
We study the regularity of solutions to the integro-differential equation $Af-λf=g$ associated with the infinitesimal generator $A$ of a Lévy process. We show that gradient estimates for the transition density can be used to derive Schauder estimates for $f$. Our main result allows us to establish Schauder estimates for a wide class of Lévy generators,
openaire   +3 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Omitting patients with no follow-up leads to bias when using inverse-intensity weighted GEEs to handle irregular and informative assessment times

BMC Medical Research Methodology
Background Longitudinal data can be used to study disease progression and are often collected at irregular intervals. When the assessment times are informative about the severity of the disease, regression analyses of the outcome trajectory over time ...
Xiawen Zhang, Anna Heath, Wei Xu, Eleanor Pullenayegum   +3 more
doaj   +1 more source

Adjusted predictions for generalized estimating equations

Biometrics
ABSTRACT Generalized estimating equations (GEEs) are a popular statistical method for longitudinal data analysis, requiring specification of the first 2 marginal moments of the response along with a working correlation matrix to capture temporal correlations within a cluster.
Francis K C Hui, Samuel Muller, Alan H Welsh   +2 more
openaire   +2 more sources

The cluster bootstrap consistency in generalized estimating equations

Journal of Multivariate Analysis, 2013
The cluster bootstrap resamples clusters or subjects instead of individual observations in order to preserve the dependence within each cluster or subject. In this paper, we provide a theoretical justification of using the cluster bootstrap for the inferences of the generalized estimating equations (GEE) for clustered/longitudinal data.
Guang Cheng, Zhuqing Yu, Jianhua Z. Huang   +2 more
openaire   +2 more sources