Results 71 to 80 of about 6,876 (298)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

On a caputo-type fractional derivative

, 2020
In this paper, we present a new differential operator of arbitrary order defined by means of a Caputo-type modification of the generalized fractional derivative recently proposed by Katugampola.
Oliveira, Daniela S, Oliveira, Edmundo Capelas de   +1 more
core   +2 more sources

Analytical Method for Solving the Fractional Order Generalized KdV Equation by a Beta-Fractional Derivative

, 2020
The present work is related to solving the fractional generalized Korteweg-de Vries (gKdV) equation in fractional time derivative form of order α. Some exact solutions of the fractional-order gKdV equation are attained by employing the new powerful ...
Majid Bagheri, Ali Khani
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Collocation Method Based on Genocchi Operational Matrix for Solving Generalized Fractional Pantograph Equations

International Journal of Differential Equations, 2017
An effective collocation method based on Genocchi operational matrix for solving generalized fractional pantograph equations with initial and boundary conditions is presented.
Abdulnasir Isah, Chang Phang, Piau Phang
doaj   +1 more source

Numerical methods of the variable-order Rayleigh-Stokes problem for a heated generalized second grade fluid with fractional derivative

, 2012
Australian Research Council [DP1094333]; Natural Science Foundation of Fujian province [2009J01014]Rayleigh-Stokes problems have in recent years received much attention due to their importance in physics.
Chen, Y., Burrage, K., 陈昌明, Chen, Chang-Ming, Liu, F., Chen, C.M.   +5 more
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Generalized Brouncker’s continued fractions and their logarithmic derivatives [PDF]

The Ramanujan Journal, 2013
In this paper, we study the continued fraction y(s,r) which satisfies the equation y(s,r)y(s+2r,r)=(s+1)(s+2r-1) for r > 1/2. This continued fraction is a generalization of the Brouncker's continued fraction b(s). We extend the formulas for the first and the second logarithmic derivatives of b(s) to the case of y(s,r).
openaire   +2 more sources