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A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao +14 more
wiley +1 more source
Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang +12 more
wiley +1 more source
On Summations of Generalized Hypergeometric Functions with Integral Parameter Differences
In this paper, we present an extension of the Karlsson–Minton summation formula for a generalized hypergeometric function with integral parameter differences.
Kirill Bakhtin, Elena Prilepkina
doaj +1 more source
Generalized Dirac Oscillator in Cosmic String Space-Time
In this work, the generalized Dirac oscillator in cosmic string space-time is studied by replacing the momentum pμ with its alternative pμ+mωβfμxμ. In particular, the quantum dynamics is considered for the function fμxμ to be taken as Cornell potential ...
Lin-Fang Deng +3 more
doaj +1 more source
Inequalities for some basic hypergeometric functions
We establish conditions for the discrete versions of logarithmic concavity and convexity of the higher order regularized basic hypergeometric functions with respect to the simultaneous shift of all its parameters.
Kalmykov S. I., Karp D. B.
doaj +1 more source
Some properties of generalized hypergeometric Appell polynomials
Let $x^{(n)}$ denotes the Pochhammer symbol (rising factorial) defined by the formulas $x^{(0)}=1$ and $x^{(n)}=x(x+1)(x+2)\cdots (x+n-1)$ for $n\geq 1$.
L. Bedratyuk, N. Luno
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STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu +5 more
wiley +1 more source
Generalized Euler integrals and A-hypergeometric functions
In their previous works the authors have introduced a holonomic system of linear differential equations associated to a certain finite set \(A\subset \mathbb{Z}^ n\). They called this system the \(A\)-hypergeometric system, and its solutions the \(A\)-hypergeometric functions.
Gelfand, I.M +2 more
openaire +1 more source
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska +4 more
wiley +1 more source

