Results 41 to 50 of about 4,681 (200)

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

open access: yesAdvanced Science, EarlyView.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao   +14 more
wiley   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

open access: yesAdvanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li   +10 more
wiley   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

open access: yesAdvanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang   +12 more
wiley   +1 more source

On Summations of Generalized Hypergeometric Functions with Integral Parameter Differences

open access: yesMathematics
In this paper, we present an extension of the Karlsson–Minton summation formula for a generalized hypergeometric function with integral parameter differences.
Kirill Bakhtin, Elena Prilepkina
doaj   +1 more source

Generalized Dirac Oscillator in Cosmic String Space-Time

open access: yesAdvances in High Energy Physics, 2018
In this work, the generalized Dirac oscillator in cosmic string space-time is studied by replacing the momentum pμ with its alternative pμ+mωβfμxμ. In particular, the quantum dynamics is considered for the function fμxμ to be taken as Cornell potential ...
Lin-Fang Deng   +3 more
doaj   +1 more source

Inequalities for some basic hypergeometric functions

open access: yesПроблемы анализа, 2019
We establish conditions for the discrete versions of logarithmic concavity and convexity of the higher order regularized basic hypergeometric functions with respect to the simultaneous shift of all its parameters.
Kalmykov S. I., Karp D. B.
doaj   +1 more source

Some properties of generalized hypergeometric Appell polynomials

open access: yesKarpatsʹkì Matematičnì Publìkacìï, 2020
Let $x^{(n)}$ denotes the Pochhammer symbol (rising factorial) defined by the formulas $x^{(0)}=1$ and $x^{(n)}=x(x+1)(x+2)\cdots (x+n-1)$ for $n\geq 1$.
L. Bedratyuk, N. Luno
doaj   +1 more source

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

open access: yesAdvanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu   +5 more
wiley   +1 more source

Generalized Euler integrals and A-hypergeometric functions

open access: yesAdvances in Mathematics, 1990
In their previous works the authors have introduced a holonomic system of linear differential equations associated to a certain finite set \(A\subset \mathbb{Z}^ n\). They called this system the \(A\)-hypergeometric system, and its solutions the \(A\)-hypergeometric functions.
Gelfand, I.M   +2 more
openaire   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska   +4 more
wiley   +1 more source

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