Results 61 to 70 of about 36,153 (203)

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

A Class of Extended Fractional Derivative Operators and Associated Generating Relations Involving Hypergeometric Functions

Axioms, 2012
Recently, an extended operator of fractional derivative related to a generalized Beta function was used in order to obtain some generating relations involving the extended hypergeometric functions [1].
H. M. Srivastava, Rakesh K. Parmar, Purnima Chopra   +2 more
doaj   +1 more source

On mini-superspace limit of boundary three-point function in Liouville field theory

, 2017
We study mini-superspace semiclassical limit of the boundary three-point function in the Liouville field theory. We compute also matrix elements for the Morse potential quantum mechanics. An exact agreement between the former and the latter is found.
Apresyan, Elena, Sarkissian, Gor
core   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

Tables of the Lauricella Hypergeometric Functions F^(3)_A

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki
The generalized hypergeometric function q​Fp​ is a power series in which the ratio of successive terms is a rational function of the summation index. The Gaussian hypergeometric functions 2F1​ and 3F3​ are most common special cases of the generalized ...
Abbasova, M.O., Ergashev, T.G.
doaj   +1 more source

Feynman integral in $\mathbb R^1\oplus\mathbb R^m$ and complex expansion of $_2F_1$

, 2016
Closed form expressions are proposed for the Feynman integral $$ I_{D, m}(p,q) = \int\frac{d^my}{(2\pi)^m}\int\frac{d^Dx}{(2\pi)^D} \frac1{(x-p/2)^2+(y-q/2)^4} \frac1{(x+p/2)^2+(y+q/2)^4} $$ over $d=D+m$ dimensional space with $(x,y),\,(p,q)\in
Pogány, Tibor K., Shpot, Mykola A.
core   +1 more source

MiR‐30a‐5p mediates epileptogenesis in epilepsy models by targeting SOX4 to regulate the Wnt/β‐catenin pathway

Epilepsia Open, EarlyView.
Abstract Objective The pathogenesis of epilepsy is closely associated with neuronal synaptic plasticity. MicroRNAs (miRNAs) can regulate various biological processes by binding to specific sequences on target genes. This study employs bioinformatics, molecular dynamics, and experimental approaches to investigate the mechanism by which MiR‐30a‐5p treats
Zhenlin Yang, Xu Zhang, Jingjing Guo, Yuanxin Wei, Jinzi Li   +4 more
wiley   +1 more source

Generalized degenerate Bernoulli numbers and polynomials arising from Gauss hypergeometric function

Advances in Difference Equations, 2021
A new family of p-Bernoulli numbers and polynomials was introduced by Rahmani (J. Number Theory 157:350–366, 2015) with the help of the Gauss hypergeometric function.
Taekyun Kim, Dae San Kim, Lee-Chae Jang, Hyunseok Lee, Hanyoung Kim   +4 more
doaj   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source