Results 71 to 80 of about 4,681 (200)

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

An Extension of the Mittag-Leffler Function and Its Associated Properties

Advances in Mathematical Physics, 2020
Inspired by certain fascinating ongoing extensions of the special functions such as an extension of the Pochhammer symbol and generalized hypergeometric function, we present a new extension of the generalized Mittag-Leffler (ML) function εa,b;p,vκz1 in ...
Gauhar Rahman, Abdus Saboor, Zunaira Anjum, Kottakkaran Sooppy Nisar, Thabet Abdeljawad   +4 more
doaj   +1 more source

Decoding Biothreats With FT‐ICR‐MS: Metabotyping of Bacillus cereus Spores Through Untargeted Metabolomics

Journal of Mass Spectrometry, Volume 61, Issue 7, July 2026.
ABSTRACT Genome sequencing is the gold standard for microbial identification. However, it fails to distinguish closely related species with overlapping genetic features. This is the case of Bacillus cereus and Bacillus cytotoxicus, two members of the B. cereus group with distinct pathogenic profiles. While B. cereus, a well‐known opportunistic pathogen
Maria Inês Romão, Inês Gomes, Wilson Antunes, Petr Novak, Marta Sousa Silva, Carlos Cordeiro   +5 more
wiley   +1 more source

Inclusion Theorems of Certain Integral Transform Related to Normalized Hypergeometric Functions and Generalized Bessel Functions

International Journal of Mathematics and Mathematical Sciences
This study explores the geometric properties of normalized Gaussian hypergeometric functions in a certain subclass of analytic functions. This work investigates the inclusion properties of integral operators associated with generalized Bessel functions ...
Manas Kumar Giri, Raghavendar K.
doaj   +1 more source

A multilayered regulatory framework linking cell wall remodelling, redox homeostasis, and metabolic plasticity during leaf development in Arabidopsis thaliana

Annals of Applied Biology, Volume 189, Issue 1, July 2026.
This study proposes a three‐layered regulatory model illustrating the transition from cell wall remodelling to redox homeostasis during leaf maturation. The model integrates structural extensibility (CESA8, XTH15), redox‐metabolic balancing (AOX1A), and transcriptional feedback mediated by NAC13.
Bayram Ali Yerlikaya
wiley   +1 more source

Integrating Radiomics and Computational Pathology to Predict Early Recurrence of Pancreatic Ductal Adenocarcinoma and Uncover Its Biological Basis in Tumor Microenvironment

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Accurate prediction of early recurrence in pancreatic ductal adenocarcinoma is vital for optimizing treatment. A novel, integrated radiomics‐pathology machine learning model successfully forecasts recurrence risks by analyzing preoperative CT images and computational pathology.
Sihang Cheng, Fuze Cong, Shenbo Zhang, Rui Lv, Wenjia Zhang, Xinyi Ke, Juncheng Wu, Zhonghe Zhao, Kui Zhao, Di Dong, Ruofan Zhang, Zhengyu Jin, Max Seidensticker, Zhiwei Wang, Huanwen Wu, Xianlin Han, Nan Hong, Huadan Xue   +17 more
wiley   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Endogenously generated Dutch‐type Aβ non‐fibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract BACKGROUND APPE693Q (“Dutch”) transgenic mice develop aging‐related learning deficits and accumulate endogenously generated non‐fibrillar aggregates (NFAs) of amyloid beta (Aβ) and amyloid precursor protein α‐carboxy terminal fragments. NFA‐Aβ correlates with synaptic loss and memory deficits more closely than does fibrillar Aβ.
Emilie L. Castranio, Merina Varghese, Elentina K. Argyrousi, Kuldeep Tripathi, Yong Huang, Akiko Asada, Linda Söderberg, Erin Bresnahan, David Lerner, Francesca Garretti, Hong Zhang, Jonathan van de Loo, Cheryl D. Stimpson, Ronan Talty, Charles Glabe, Efrat Levy, Minghui Wang, Marjan Ilkov, Toshiharu Suzuki, Kanae Ando, Bin Zhang, Lars Lannfelt, Brigitte Guérin, William D. Lubell, Shai Rahimipour, Dara L. Dickstein, Sam Gandy, Ottavio Arancio, Michelle E. Ehrlich   +28 more
wiley   +1 more source

Integrative Transcriptomic Signature of tRNA‐Derived Fragment Targets and Lactylation‐Related Genes for Prostate Cancer Diagnosis

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Conventional diagnostic strategies for prostate cancer (PCa) are hindered by suboptimal specificity, frequently resulting in overdiagnosis and unnecessary invasive biopsies. We developed an integrative diagnostic framework based on transcriptomic signatures from tRNA‐derived fragments (tRFs), target genes, and lactylation‐related ...
Lei Wang, Xiaoxue Hu, Bixi Wang, Yaping Zhang, Jiajia Yang, Ying Wang   +5 more
wiley   +1 more source

SGO1 and SGO2 are Associated With Disease Progression and an Immunosuppressive Microenvironment in Papillary Renal Cell Carcinoma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Shugoshin proteins SGO1 and SGO2 regulate chromosome cohesion and segregation during mitosis and meiosis, and their aberrant expression is implicated in several cancers. However, the mechanistic involvement of these two proteins in papillary renal cell carcinoma (KIRP) and their contribution to immune evasion remains unclear ...
Han Fu, Alisherjon Ibrohimov, Hao Zheng, Yue Pan, Jieyu Hu, Banzhan Ruan, Hang Huang, Shi Li   +7 more
wiley   +1 more source