Results 41 to 50 of about 499 (215)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Degenerate‐Generalized Likelihood Ratio Test for One‐Sided Composite Hypotheses [PDF]

Mathematical Problems in Engineering, 2012
We propose the degenerate‐generalized likelihood ratio test (DGLRT) for one‐sided composite hypotheses in cases of independent and dependent observations. The theoretical results show that the DGLRT has controlled error probabilities and stops sampling with probability 1 under some regularity conditions.
Xiang, Dongdong, Pu, Xiaolong, Wang, Lei, Li, Yan   +3 more
openaire   +2 more sources

A Particle Filtering Approach to Change Detection for Nonlinear Systems

EURASIP Journal on Advances in Signal Processing, 2004
We present a change detection method for nonlinear stochastic systems based on particle filtering. We assume that the parameters of the system before and after change are known.
P. S. Krishnaprasad, Babak Azimi-Sadjadi   +1 more
doaj   +1 more source

An Effective Baseline Correction Algorithm Using Broad Gaussian Vectors for Chemical Agent Detection with Known Raman Signature Spectra

Sensors, 2021
Raman spectroscopy, which analyzes a Raman scattering spectrum of a target, has emerged as a key technology for non-contact chemical agent (CA) detection. Many CA detection algorithms based on Raman spectroscopy have been studied.
Hyeong Geun Yu, Dong Jo Park, Dong Eui Chang, Hyunwoo Nam   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Phase-Based GLRT Detection of Moving Targets with Pixel Tracking in Low-Resolution SAR Image Sequences

Remote Sensing, 2021
Spaceborne synthetic aperture radar (SAR) can provide ground area monitoring with large coverage. However, achieving a wide observation scope comes at the cost of resolution reduction owing to the trade-off between these parameters in conventional SAR ...
Yulun Li, Chunsheng Li, Xiaodong Peng, Shuo Li, Hongcheng Zeng, Wei Yang   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Estimation and Statistical tests For the Parameters of Multiple Linear Generalized Modified Bessel Regression Model [PDF]

المجلة العراقية للعلوم الاحصائية, 2013
This paper is concerned with the estimation and statistical tests of hypothesises around parameters of generalized modified Bessel linear regression model by Non-Bayesian (classical) techniques under the assumption that the shape parameters ( ) are known
doaj   +1 more source