Results 71 to 80 of about 387,662 (285)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Gaussian ISI channels and the generalized likelihood ratio test [PDF]

2000 IEEE International Symposium on Information Theory (Cat. No.00CH37060), 2002
Decoders employing the generalized likelihood ratio test can achieve rates that can be achieved by maximum likelihood decoders on ISI channels even though they are ignorant of the channel characteristics.
A. Lapidoth, E. Telatar
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Adaptive Energy Detector and Its Application for Mismatched Signal Detection(in English)

Leida xuebao, 2015
We investigate several important properties of an Adaptive Energy Detector (AED), which is originally proposed according to the Generalized Likelihood Ratio Test (GLRT), under the assumption that the signal steering vector is completely unknown.
Liu Wei-jian, Wang Li-cai, Di Yuan-shui, Jian Tao, Xie Dang, Wang Yong-liang   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Extension of a Fast GLRT Algorithm to 5D SAR Tomography of Urban Areas

Remote Sensing, 2017
This paper analyzes a method for Synthetic Aperture Radar (SAR) Tomographic (TomoSAR) imaging, allowing the detection of multiple scatterers that can exhibit time deformation and thermal dilation by using a CFAR (Constant False Alarm Rate) approach.
Alessandra Budillon, Angel Caroline Johnsy, Gilda Schirinzi   +2 more
doaj   +1 more source

Deciphering hierarchical organization of topologically associated domains through change-point testing

BMC Bioinformatics, 2021
Background The nucleus of eukaryotic cells spatially packages chromosomes into a hierarchical and distinct segregation that plays critical roles in maintaining transcription regulation.
Haipeng Xing, Yingru Wu, Michael Q. Zhang, Yong Chen   +3 more
doaj   +1 more source

Generalization of likelihood ratio tests under nonstandard conditions

The Annals of Statistics, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Vu, H. T. V., Zhou, S.
openaire   +3 more sources