Results 91 to 100 of about 373,771 (313)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

State-space approach to nonlinear predictive generalized minimum variance control

, 2010
A Nonlinear Predictive Generalized Minimum Variance (NPGMV) control algorithm is introduced for the control of nonlinear discrete-time multivariable systems.
Majecki, P.M., Grimble, M.J., EPSRC on the Platform Grant Project No EP/C526422/1 (Funder), , EPSRC on the Platform Grant Project No EP/C526422/1 (Funder)   +3 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Generalized Partially Functional Linear Model with Interaction between Functional Predictors

Axioms
This paper proposes a generalized partially functional linear model with interaction terms. It is suitable for cases where the response variable is scalar, and the predictor variables include a mix of functional and scalar types, while considering the ...
Weiwei Xiao, Kejing Mao, Haiyan Liu
doaj   +1 more source

Robust Inference in Generalized Linear Models

Communications in Statistics - Simulation and Computation, 2016
Robust inference on the parameters in generalized linear models is performed using the weighted likelihood method. Two cases are considered: a case with replicated observations and a case with a single observation of the dependent variable for each combination of the explanatory variables.
Alqallaf, Fatemah, Agostinelli, Claudio
openaire   +3 more sources

Estimation for Generalized Linear Models When Covariates Are Subject-specific Parameters in a Mixed Model for Longitudinal Measurements

, 2005
In many studies, a primary endpoint and longitudinal measures of a continuous response are collected for each participant along with other covariates, and the association between the primary endpoint and features of the longitudinal profiles is of ...
Li, Erning
core  

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Exploring Global Temperature Oscillations Using a Generalized Linear Box Model

Geophysical Research Letters
Solutions including oscillatory responses to monotonic forcing are derived for a generalized energy balance box model, and used to help explore general circulation model (GCM) global surface temperature responses to CO2 forcing.
Hege‐Beate Fredriksen, Kai‐Uwe Eiselt, Peter Good   +2 more
doaj   +1 more source

PENGARUH VARIAN EFEK ACAK TERHADAP PENGESTIMASIAN EFEK TETAP DALAM MODEL POISSON-GAMMA PADA HGLM (HIERARCHICAL GENERALIZED LINEAR MODEL)

, 2013
RINGKASAN Pengaruh Varian Efek Acak Terhadap Pengestimasian Efek Tetap dalam Model Poisson-Gamma pada HGLM (Hierarchical Generalized Linear Model); Siskha Kusumaningtyas; 2013; 50 Halaman; Jurusan Matematika Fakultas Matematika dan Ilmu ...
Siskha Kusumaningtyas
core  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source