Results 81 to 90 of about 17,406,387 (286)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
INTUITIONISTIC FUZZY STRONGLY α-GENERALIZED SEMI CLOSED SETS
Journal of New Theory, 2015 In this paper, intuitionistic fuzzy strongly α-generalized semi closed sets and in- tuitionistic fuzzy strongly α-generalized open sets are introduced.
Annasamy Yuvarani +3 more
doaj
, 2011 A new class of generalized fuzzy open sets in fuzzy topological space, called fuzzy sp-open sets, are introduced, and their properties are studied and the relationship between this new concept and other weaker forms of fuzzy open sets we discussed ...
Hakeem A. Othman
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Generalized open sets and selection properties
Filomat, 2019 We define and study new weak versions of the classical Menger covering property. For this we use ?-open and ?-open covers of a topological space. Relations of these properties with known weak versions of the Menger property are examined. In this way we complement the study of weak covering properties defined by selection principles.
openaire +3 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
SOFT π-OPEN SETS IN SOFT GENERALIZED TOPOLOGICAL SPACES
Journal of New Theory, 2015 The main purpose of this paper is to study some interesting properties of the soft mapping π : S(U)E → S(U)E which satisfy the condition πFB ⊂ πFD whenever FB ⊂ FD ⊂ ̃.
Jyothis Thomas, Sunil Jacob John
doaj
Generalized and Customizable Sets in R [PDF]
We present data structures and algorithms for sets and some generalizations thereof (fuzzy sets, multisets, and fuzzy multisets) available for R through the sets package. Fuzzy (multi-)sets are based on dynamically bound fuzzy logic families.
Kurt Hornik, David Meyer
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source