Results 91 to 100 of about 79,508 (290)

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Directional functional coupling during limbic seizures in rats revealed by nonlinear Granger causality

Russian Open Medical Journal, 2018
Subject and Purpose — Temporal lobe epilepsy is increasingly recognized to involve widespread network alterations. In this study the temporal dynamics of directional interactions between the frontal cortex, hippocampus, thalamus and midbrain during ...
Ilya V. Sysoev, Martin F.J. Perescis, Lyudmila V. Vinogradova, Marina V. Sysoeva, Clementina M. van Rijn   +4 more
doaj   +1 more source

Neuronal Desynchronization as a Trigger for Seizure Generation

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2008
Experimental reports have appeared which challenge the dogma that epileptic seizures arise as a consequence of neuronal hypersynchronization. We sought to explore what mechanisms that desynchronize neuronal firing could induce epileptic seizures. A computer model of connections in a mammalian hippocampal slice preparation was constructed including two ...
Yue, Li, Ioana Nicolaescu, Fleming, Mustafa Efkan, Colpan, David J, Mogul   +3 more
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Investigação de alterações no nível e na ativação de proteínas cinases no neocórtex e no hipocampo de camundongos submetidos ao modelo de kindling por pentilenotetrazol [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2014.A epileptogênese é um processo que envolve a sinalização celular e a neuroplasticidade. As proteínas
Ben, Juliana
core  

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Imaging haemodynamic changes related to seizures: comparison of EEG-based general linear model, independent component analysis of fMRI and intracranial EEG

, 2010
Background: Simultaneous EEG-fMRI can reveal haemodynamic changes associated with epileptic activity which may contribute to understanding seizure onset and propagation. Methods: Nine of 83 patients with focal epilepsy undergoing pre-surgical evaluation
Laufs, H., Lhatoo, S., Guye, M., Rodionov, R., McEvoy, A., Carmichael, D., Thornton, R.C., Vulliemoz, S., Cannadathu, S., Vaudano, A.   +9 more
core  

Altered relationship between thickness and intrinsic activity amplitude in generalized tonic-clonic seizures

, 2016
A thinner cortex has higher potential for binding GABA receptor A which is associated with larger amplitudes of intrinsic brain activity (iBA). However, the relationship between cortical thickness and iBA is unknown in intact and epileptic brains.
Wang, Jue, Lu, Guangming, Qiu, Anqi, H. Chen, Wang, Zhengge, Chen, Huafu, Liao, Wei, Xu, Qiang, Zang, Yu-Feng, Zhang, Zhiqiang, Zuo, Xi-Nian, Ji, Gong-Jun, Yang, Fang, Xu, Ting, G. Lu   +14 more
core   +1 more source

BRAIN BIOELECTRIC ACTIVITY IN CHILDREN WITH IDIOPATHIC EPILEPSY

Эпилепсия и пароксизмальные состояния, 2018
The aim was to study the bioelectrical activity of the brain in children with idiopathic epilepsy. Using clinical, neurological and neurophysiological methods, we examined 60 children (32 boys, 53% and 28 girls, 47%) aged 5 to 10 years old.Results.
Yo. N. Majidova, M. I. Abdullayeva
doaj   +1 more source