Results 61 to 70 of about 79,508 (290)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Adjunctive therapy for the treatment of primary generalized tonic-clonic seizures: focus on once-daily lamotrigine

, 2010
Linda Steinbaugh, Jerzy P SzaflarskiDepartment of Neurology and Cincinnati Epilepsy Center, University of Cincinnati Academic Health Center, Cincinnati, Ohio, USAAbstract: Idiopathic generalized epilepsies are frequently encountered by neurologists, and ...
Jerzy Szaflarski, null Linda Steinbaugh, MD, Linda Steinbaugh, Jerzy P Szaflarski   +3 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The clinical convulsive profile in children admitted in the Department of paediatrics in Qena University Hospital; Epidemiological study

SVU - International Journal of Medical Sciences, 2020
Background: Seizures are a potentially life threatening problem with a variety of causes. Objectives: The current study aimed to recognize different patterns of convulsions among children and identify different causes of convulsions in children with ...
Khaled A. Abdelbasser, Abdalla H. Khalafalla*, Ali H. Bakri   +2 more
doaj   +1 more source

Clinical and Electrophysiological Characteristics of Patients with Juvenile Absence Epilepsy in a Turkish Cohort

Genel Tıp Dergisi, 2022
Juvenile absence epilepsy is an epileptic syndrome that usually begins between the ages of 9-13 and is classified in the group of genetic generalized epilepsies, in which absence seizures are seen mainly but may also be accompanied by motor seizures in ...
Bülent Kara, Ömer Karaca, Defne Alikılıç, Adnan Deniz, Merve Öztürk, Mesut Güngör   +5 more
doaj   +1 more source

Generalization mechanisms of limbic seizures

Pathophysiology, 1994
It is well known that complex partial seizures of temporal origin may evolve into secondarily generalized convulsive seizures. For this reason, amygdaloid kindling, which begins with limbic seizures and culminates in secondarily generalized convulsions, is considered to be a useful model for examination of mechanisms underlying the development of ...
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

VARIANTS OF THE GENERALIZATION OF EPILEPTIC SEIZURES IN MESIAL TEMPORAL EPILEPSY IN ADULTS

Эпилепсия и пароксизмальные состояния, 2016
The purpose of work was to study polymorphism of kinematic variants of secondary generalized convulsive seizures by research of lesional and non-lesional mesial temporal epilepsy. For this purpose the patients suffering by non-lesional variants of mesial
V. О. Generalov, Т. R. Sadykov, Yu. ВV. Kazakova, Е. V. Amcheslavskaya   +3 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source