Results 81 to 90 of about 4,306,668 (246)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Stochastic models (cooperative and non-cooperative) for NMR analysis of the hetero-association of aromatic molecules in aqueous solution [PDF]

open access: yes, 2006
Stochastic cooperative (STOCH-C) and non-cooperative (STOCH-NC) models have been developed for NMR analysis of the hetero-association of aromatic compounds in solution, in order to take into account all physically meaningful association reactions of ...
Veselkov, A.N.   +2 more
core   +1 more source

New singular solutions for the (3+1)-D Protter problem

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2018
For the nonhomogeneous wave equation with three space and one time variables we study a boundary value problem that can be regarded as a four-dimensional analogue of the Darboux problem in R2.
T.P. Popov
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

On solutions of Hamilton-Jacobi equations with exponential dependence on momentum

open access: yesСовременная математика: Фундаментальные направления
Three initial problems for one-dimensional Hamilton-Jacobi equations of evolutionary type are considered on a bounded time segment. In all problems, the Hamiltonians depend on the coordinate and momentum variables.
L. G. Shagalova
doaj   +1 more source

Asymptotic behavior of solutions of nonlinear functional differential equations

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1994
Using the properties of almost nonexpansive curves introduced by B. Djafari Rouhani, we study the asymptotic behavior of solutions of nonlinear functional differential equation du(t)/dt+Au(t)+G(u)(t)?f(t), where A is a maximal monotone operator in a ...
Jong Soo Jung   +2 more
doaj   +1 more source

A generalized class one static solution

open access: yesHeliyon, 2019
In literature, there are three simplest methods of solving Einstein's field equations, namely, (a) assuming conformally flat spacetime, (b) using conformal killing vector and (c) using Karmarkar conditions.
Ksh. Newton Singh   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Solution of RE Models with Anticipated Shocks and Optimal Policy [PDF]

open access: yes
The purpose of this paper is to solve linear dynamic rational expectations models with anticipated shocks by using the generalized Schur decomposition method. We also determine the optimal unrestricted and restricted policy responses to temporary as well
Wohltmann, Hans-Werner   +1 more
core  

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