Results 121 to 130 of about 17,517,320 (360)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Generating Focused Molecule Libraries for Drug Discovery with Recurrent Neural Networks
ACS Central Science, 2017 In de novo drug design, computational strategies are used to generate novel molecules with good affinity to the desired biological target. In this work, we show that recurrent neural networks can be trained as generative models for molecular structures ...
Marwin H. S. Segler +3 more
semanticscholar +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Explicit expression for the generating function counting Gessel's walks [PDF]
, 2010 Gessel's walks are the planar walks that move within the positive quadrant $\mathbb{Z}_{+}^{2}$ by unit steps in any of the following directions: West, North-East, East and South-West.
Kurkova, Irina, Raschel, Kilian
core +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Weighted hypergeometric functions and fractional derivative
Advances in Difference Equations, 2017 We introduce some weighted hypergeometric functions and the suitable generalization of the Caputo fractional derivation. For these hypergeometric functions, some linear and bilinear relations are obtained by means of the mentioned derivation operator ...
JE Restrepo +3 more
doaj +1 more source
The Weak Bruhat Order and Separable Permutations [PDF]
, 2010 In this paper we consider the rank generating function of a separable permutation $\pi$ in the weak Bruhat order on the two intervals $[\text{id}, \pi]$ and $[\pi, w_0]$, where $w_0 = n,(n-1),..., 1$. We show a surprising result that the product of these
Wei, Fan
core
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Technological and Economic Development of Economy, 2008 In this paper a mathematical model for obtaining probability distribution of the knowledge testing results is proposed. Differences and similarities of this model and Item Response Theory (IRT) logistic model are discussed.
Aleksandras Krylovas, Natalja Kosareva
doaj +1 more source
Hypergeometric Generating Function of L-function, Slater's Identities, and Quantum Invariant
, 2004 We study certain connections between the quantum invariants of the torus knots T_{3,2^k} and some q-series identities.
Anatol, Kazuhiro Hikami, N. Kirillov
core +1 more source