Results 81 to 90 of about 1,461,187 (297)

Sniper: scalable and accurate parallel multi-core simulation [PDF]

, 2012
Sniper is a next generation parallel, high-speed and accurate x86 simulator. This multi-core simulator is based on the interval core model and the Graphite simulation infrastructure, allowing for fast and accurate simulation and for trading off ...
Carlson, Trevor, Eeckhout, Lieven, Heirman, Wim   +2 more
core  

Second-generation p-values: improved rigor, reproducibility, & transparency in statistical analyses

, 2017
Verifying that a statistically significant result is scientifically meaningful is not only good scientific practice, it is a natural way to control the Type I error rate.
Blume, Jeffrey D., Dupont, William D., Greevy, Robert A., McGowan, Lucy DAgostino   +3 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

An Optimization Method for Day-Ahead Generation Interval of Cascade Hydropower Adapting to Multi-Source Coordinated Scheduling Requirements

Energies
Multi-source coordinated scheduling has become the predominant operational paradigm in power systems. However, substantial differences among hydropower, thermal power, wind power, and photovoltaic sources in terms of response speed, regulation capability,
Shushan Li, Chonghao Li, Huijun Wu, Zhipeng Zhao, Huan Wang, Yongxi Kang, Chuntian Cheng, Changhong Li   +7 more
doaj   +1 more source

Effects of Chronic Waterborne Nickle Exposure on Two Successive Generations of \u3cem\u3eDaphnia Magna\u3c/em\u3e [PDF]

, 2004
In a 21-d chronic toxicity test in which an F0 generation of Daphnia magna were exposed to waterborne Ni, the noobservable-effect concentration (for survival, reproduction, and growth) was 42 μg Ni L-1, or 58% of the measured 21-d median lethal ...
McGeer, James C., Pane, Eric F., Wood, Chris M.   +2 more
core   +1 more source

Supernovae - Optical Precursors of Short Gamma-Ray Bursts

, 2011
The probability of observing "supernova - gamma-ray burst" (GRB) pair events and recurrent GRBs from one galaxy in a time interval of several years has been estimated.
A. G. Kuranov, A. King, A. MacFadyen, A. Rujula De, B. Paczynski, C. Meegan, E. Babichev, G. D. Quinlan, G. V. Lipunova, H. Mouri, J. G. Hills, K. A. Postnov, K. S. Cheng, L. P. Grishchuk, L. Stella, M. B. Davies, M. Ruffert, M. T. Murphy, R. H. Sanders, S. A. Colgate, S. Graziani, S. I. Blinnikov, S. L. Shapiro, V. I. Dokuchaev, V. I. Dokuchaev, V. I. Dokuchaev, V. I. Dokuchaev, V. Lipunov, V. S. Berezinsky, V. S. Berezinsky, V. S. Imshennik, V. S. Imshennik, V. S. Imshennik, V. S. Imshennik, W. Hillebrandt, Y. N. Efremov, Ya. B. Zel’dovich, Ya. Yu. Tikhomirova, Yu. N. Eroshenko   +38 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source