Results 101 to 110 of about 495,921 (307)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Epidemics, 2019 Infectious disease outbreaks are often characterized by the reproduction number R and exponential rate of growth r. R provides information about outbreak control and predicted final size, but estimating R is difficult, while r can often be estimated ...
Sang Woo Park +3 more
doaj +1 more source
A Generalized Interval LU Decomposition for the Solution of Interval Linear Systems [PDF]
, 2007 Generalized intervals (intervals whose bounds are not constrained to be increasingly ordered) extend classical intervals providing better algebraic properties. In particular, the generalized interval arithmetic is a group for addition and for multiplication of zero free intervals.
Goldsztejn, Alexandre, Chabert, Gilles
openaire +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Generation interval and mean age at birth of the offspring in the reference population.
, 2022 Generation interval and mean age at birth of the offspring in the reference population.
Ladislav Tichý (14106693) +4 more
core +1 more source
Generation of an Interval Metric Scale to Measure Attitude
SAGE Open, 2014 This article discusses issues of scales in measuring attitude, demonstrates how a metric scale can be generated based on three main features, and presents results from a repeated measurement survey to verify the generated scale.
Rohana Yusoff, Roziah Mohd Janor
doaj +1 more source
Inferring the differences in incubation-period and generation-interval distributions of the Delta and Omicron variants of SARS-CoV-2. [PDF]
Proc Natl Acad Sci U S A, 2023 Park SW +11 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Optimum breeding generation interval considering buildup of relatedness
, 2001 Models taking genetic gain, relatedness, delay at generation turnover, and breeding population size into account have been developed to optimize selection age and generation interval. Relatedness (expressed as group coancestry) and average breeding value
R -P Wei, D Lindgren
core +1 more source
Estimation of the generation interval using pairwise relative transmission probabilities. [PDF]
Biostatistics, 2022 Leavitt SV +6 more
europepmc +1 more source