Results 111 to 120 of about 4,042,263 (299)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Monotonicity Problems of Interval Solutions and the Dutta-Ray Solution for Convex Interval Games [PDF]

This paper examines several monotonicity properties of value-type interval solutions on the class of convex interval games and focuses on the Dutta-Ray (DR) solution for such games.
Brânzei, R., Tijs, S.H., Yanovskaya, E.
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Cooperation under Interval Uncertainty [PDF]

Classification: JEL code C71Cooperative game theory;Interval uncertainty;Core;Value ...
Miquel, S., Tijs, S.H., Alparslan-Gok, S.Z.   +2 more
core  

Solving the linear interval tolerance problem for weight initialization of neural networks [PDF]

, 2014
Determining good initial conditions for an algorithm used to train a neural network is considered a parameter estimation problem dealing with uncertainty about the initial weights.
Adam, S.P., Karras, D.A., Vrahatis, M.N., Magoulas, George D.   +3 more
core   +1 more source

The importance of the generation interval in investigating dynamics and control of new SARS-CoV-2 variants. [PDF]

J R Soc Interface, 2022
Park SW, Bolker BM, Funk S, Metcalf CJE, Weitz JS, Grenfell BT, Dushoff J.   +6 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cournot oligopoly interval games [PDF]

In this paper we consider cooperative Cournot oligopoly games. Following Chander and Tulkens (1997) we assume that firms react to a deviating coalition by choosing individual best reply strategies.
Aymeric Lardon
core  

Generation of Interval-Valued Fuzzy Negations from Trillas’ Theorem. The Case of Interval Type-2 Fuzzy Sets

, 2015
In this work we introduce a method for building interval-valued negations using the characterization theorem for strong negations which was proposed by Trillas in 1979.
M. Pagola, J. Montero, Barrenechea, Edurne, Fernández Castillo, Jesús, Montero De Juan, Francisco Javier, Bustince, Humberto, Pagola, Miguel, J. Fernández, H. Bustince, E. Barrenechea   +9 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source