Results 111 to 120 of about 495,921 (307)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A branch-and-price algorithm for a hierarchical crew scheduling problem. [PDF]

We describe a real-life problem arising at a crane rental company. This problem is a generalization of the basic crew scheduling problem given in Mingozzi et al. and Beasley and Cao.
Woeginger, G, Faneyte, D, Spieksma, Frederik   +2 more
core  

Interval optimal reactive power reserve dispatch considering generator rescheduling

, 2016
© The Institution of Engineering and Technology 2016. Owing to the variations of loads and sustainable energy, the power injections and the load increment direction are of uncertainties, which pose great challenges to the traditional models of power ...
Cheng, Haozhong, Zhu, Zhonglie, Yao, Liangzhong, Fang, Sidun, Ma, Zeliang, Zeng, Pingliang, Song, Yue   +6 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The importance of the generation interval in investigating dynamics and control of new SARS-CoV-2 variants. [PDF]

J R Soc Interface, 2022
Park SW, Bolker BM, Funk S, Metcalf CJE, Weitz JS, Grenfell BT, Dushoff J.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Interval priority weight generation from interval comparison matrices in analytic hierarchy process

, 2009
In this study, for the well-known Analytic Hierarchy Process (AHP) method a new approach to interval priority weight generation from interval comparison matrix is proposed. This method can be used for both inconsistent and consistent matrices.
UFUK ÖZTÜRK
core  

MB-Representations of Algebras Generated by Intervals

Real Analysis Exchange, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

First and second births among immigrants and their descendants in Switzerland

Demographic Research, 2018
Background: The fertility of immigrants and their descendants is a crucial determinant of population dynamics, particularly where migrants are numerous and ethnically diverse, as in Switzerland. This paper analyses the transition to the first and second
Eder Andres Guarin Rojas, Laura Bernardi, Flurina Schmid   +2 more
doaj   +1 more source