Results 81 to 90 of about 1,468,908 (292)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Caracterização demográfica da raça Mangalarga Marchador Demographic characterization of Mangalarga Marchador breed

open access: yesArquivo Brasileiro de Medicina Veterinária e Zootecnia, 2004
Data from the Brazilian Mangalarga Marchador Breed Association, including information on 292,012 animals borned from 1949 to 2000 were used to describe population structure. Frequency tables, central tendency and variation measurements according to owner,
M.D. Costa   +4 more
doaj   +1 more source

A Generation of Information Anxiety: Refinements and Recommendations

open access: yes, 2017
Richard Saul Wurman’s groundbreaking Information Anxiety (1989) was published exactly one generation ago. The passage of time has allowed information specialists to reflect further upon the notion of information anxiety and such related concepts as “info-
Hartog, Paul
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

A raça Indubrasil no Nordeste brasileiro: melhoramento e estrutura populacional The Indubrasil breed in the Brazilian Northeast: breeding and population structure

open access: yesRevista Brasileira de Zootecnia, 2009
Com o intuito de fornecer subsídios para programas de melhoramento, conservação e expansão da raça Indubrasil do Nordeste brasileiro, avaliaram-se o histórico evolutivo, as estimativas de parâmetros genéticos e a estrutura populacional da raça.
Paulo Luiz Souza Carneiro   +5 more
doaj   +1 more source

Rapid review of available evidence on the serial interval and generation time of COVID-19

open access: yesBMJ Open, 2020
Objective Conduct a review of available evidence to advise on appropriate parameter values for serial interval and generation time in national COVID-19 transmission models for Ireland and on methodological issues relating to those parameters.Methods We ...
Andrew Byrne   +9 more
doaj   +1 more source

Robust entanglement generation by reservoir engineering

open access: yes, 2012
Following a recent proposal [C. Muschik et. al., Phys. Rev. A 83, 052312 (2011)], engineered dissipative processes have been used for the generation of stable entanglement between two macroscopic atomic ensembles at room temperature [H. Krauter et.
Cirac, J. Ignacio   +5 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

An Optimization Method for Day-Ahead Generation Interval of Cascade Hydropower Adapting to Multi-Source Coordinated Scheduling Requirements

open access: yesEnergies
Multi-source coordinated scheduling has become the predominant operational paradigm in power systems. However, substantial differences among hydropower, thermal power, wind power, and photovoltaic sources in terms of response speed, regulation capability,
Shushan Li   +7 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

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