Results 141 to 150 of about 10,994,854 (357)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual-Layer Detector Cone-Beam CT Angiography for Stroke Assessment: First-in-Human Results (the Next Generation X-ray Imaging System Trial). [PDF]

AJNR Am J Neuroradiol, 2023
Ståhl F, Almqvist H, Kolloch J, Aspelin Å, Gontu V, Hummel E, van Vlimmeren M, Simon M, Thran A, Holmberg Å, Mazya MV, Söderman M, Delgado AF.   +12 more
europepmc   +1 more source

High-nonlinearity dispersion-shifted lead-silicate holey fibers for efficient 1-µm pumped supercontinuum generation

, 2006
This paper reports on the recent progress in the design and fabrication of high-nonlinearity lead-silicate holey fibers (HFs). First, the fabrication of a fiber designed to offer close to the maximum possible nonlinearity per unit length in this glass ...
Leong, J.Y.Y., Asimakis, S., Moore, R., Richardson, D.J., K.E. Frampton, J.H.V. Price, R.C. Moore, H. Ebendorff-Heidepriem, Price, J.H.V., S. Asimakis, D.J. Richardson, Monro, T.M., Moore, R.C., X. Feng, Richardson, D., Frampton, K.E., Petropoulos, P., Monro, T., Ebendorff-Heidepriem, H., Price, J., T.M. Monro, V. Finazzi, Frampton, K., Leong, J., Finazzi, V., J.Y.Y. Leong, P. Petropoulos, Feng, X.   +27 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Parametric X-ray radiation for calibration of X-ray space telescopes and generation of several X-ray beams

, 2001
ThéorieThe setup based on a moderate energy linear accelerator (linac) is proposed to provide users with a tunable, quasi-monochromatic, linearly polarized X-ray beam.
Fiorito, R.B., Shchagin, A.V., Artru, X., Rule, D.W., Khiznyak, N.A.   +4 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Generation X och generation Y:s förväntningar på ledarskap och ledarstilar : En kvalitativ studie gällande generation X och generation Y:s förväntningar på ledarskap samt föredragen ledarskapsstil

, 2023
Den svenska arbetsmarknaden står inför stora förändringar gällande generationer. Baby boom generationen kommer inom snar framtid att gå i pension och generation X och generation Y tar över arbetsmarknaden.
Marjanovic, Mikaela, Linderos, Emma
core   +1 more source

The Role of Positive and Negative Information Processing in COVID-19 Vaccine Uptake in Women of Generation X, Y, and Z: The Power of Good is Stronger Than Bad in Youngsters? [PDF]

Front Psychol, 2022
Marschalko EE, Szabo K, Kotta I, Kalcza-Janosi K.   +3 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source