Results 151 to 160 of about 10,994,854 (357)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Multigenerational workforce and organizational performance: A convergent analysis

International Journal of Academe and Industry Research
The composition of today's workforce has experienced a notable increase in age diversity with four generations working together. The purpose of the study was to explore the influence of a multigenerational workforce on organizational performance ...
Chilufya C. Chiwisa, Mubanga Mpundu
doaj   +1 more source

TerraSAR-X System Performance and Command Generation

, 2008
The paper starts with an overview about the TS-X data take command generation. The general approach of calculating particular instrument settings for each data acquisition is presented.
Steinbrecher, Ulrich, Schulze, Daniel, Meta, Adriano, Ortega-Miguez, Carlos, Wollstadt, Steffen, Mittermayer, Josef, Marquez-Martinez, Jose, Younis, Marwan, Tous-Ramon, Nuria   +8 more
core  

A search-based approach for automatic test generation from extended finite state machine (EFSM)

, 2009
The extended finite state machine is a powerful model that can capture almost all the aspects of a system. However, testing from an EFSM is yet a challenging task due to two main problems: path feasibility and path test data generation.
AbdulSalam Kalaji, Stephen Swift, Swift, S, Kalaji, AS, Hierons, RM, Rob Mark Hierons   +5 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

[Sexist relationships in Generation X and Millennials]. [PDF]

Aten Primaria, 2021
Rubio-Laborda JF, Almansa-Martínez P, Pastor-Bravo MDM.   +2 more
europepmc   +1 more source

Quality assessment of TanDEM-X Raw DEMs oriented to a fusion with CartoSAT-1 DEMs

, 2013
This paper addresses a quality assessment of TanDEM-X standard Raw DEMs, with a resolution of 12 meters, for three different terrain configurations: urban areas, moderate topography and complex topography.
Reinartz, Peter, d'Angelo, Pablo, Eineder, Michael, Rossi, Cristian, Fritz, Thomas   +4 more
core  

The TerraSAR-X Mission and System Design

, 2010
This paper describes the TerraSAR-X Mission Concept within the context of a public-private-partnership (PPP) agreement between the German Aerospace Center DLR and industry. It briefly describes the PPP-concept as well as the overall project organization.
Werninghaus, Rolf, Buckreuß, Stefan
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source