Results 161 to 170 of about 9,521,765 (295)

The acceptance of evolution: A developmental view of Generation X in the United States. [PDF]

open access: yesPublic Underst Sci
Miller JD   +5 more
europepmc   +1 more source

Coherence properties of the high-energy fourth-generation X-ray synchrotron sources. [PDF]

open access: yesJ Synchrotron Radiat, 2019
Khubbutdinov R   +2 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Von Generation zu Generation

open access: yes, 2002
Am 14. Juni 2002 fand im Rahmen der Ehrung und Wuerdigung von Prof.Dr. Max Kaase, Prof.Dr. Walter Mueller und Prof.Dr. Hansgert Peisert fuer ihre langjaehrige und richtungsweisende Abeit in der Mitgliederversammlung des ZUMA e.V.
Zentrum fuer Umfragen, Methoden und Analysen -ZUMA-, Mannheim (Germany)   +1 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Efficient near-infrared supercontinuum generation in tellurite holey fiber pumped 320nm within the normal dispersion regime

open access: yes, 2010
We demonstrate the generation of a 1.1-1.7µm supercontinuum in a 1.3m long air suspended-core tellurite holey-fiber with a nominal zero-dispersion wavelength of ~1.38µm. The fiber is pumped at 1.06µm with a 20ps pulsed fiber laser.
Horak, P.   +9 more
core  

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