Results 21 to 30 of about 331,887 (241)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Auxiliary Deep Generative Models [PDF]

, 2016
Deep generative models parameterized by neural networks have recently achieved state-of-the-art performance in unsupervised and semi-supervised learning.
Maaløe, Lars, Sønderby, Casper Kaae, Sønderby, Søren Kaae, Winther, Ole   +3 more
core   +1 more source

Nonparametric Bayes Modeling of Populations of Networks

, 2016
Replicated network data are increasingly available in many research fields. In connectomic applications, inter-connections among brain regions are collected for each patient under study, motivating statistical models which can flexibly characterize the ...
Dunson, David B., Durante, Daniele, Vogelstein, Joshua T.   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Attitude of Students and Teachers to AI: Cluster Analysis

Вопросы образования
The article provides an overview of current research on the current state of generative artificial intelligence. The authors of the article conducted a cluster analysis of data obtained from a survey of 1,597 students and 250 professors at Tomsk State ...
Kristina I. Buyakova, Yakov A. Dmitriev, Arina S. Ivanova, Tatyana V. Kabanova, Artem V. Feshchenko   +4 more
doaj   +1 more source

The Potential Use of Artificial Intelligence in ESL Writing Assessment: A Case Study of IELTS Writing Tasks

Irish Journal of Technology Enhanced Learning, 2023
This paper investigates the potential use of generative AI in ESL Writing Assessment, particularly in IELTS Writing Tasks. The first part introduces the author’s relationship with generative AI in the educational setting, and why the author chooses this
Tianhe Sun
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Advancing Students’ Academic Excellence in Distance Education: Exploring the Potential of Generative AI Integration to Improve Academic Writing Skills

Open Praxis
This qualitative study explores the potential of generative artificial intelligence (AI) to improve the academic writing skills of a large student cohort within the context of a distance learning institution.
Kgabo Bridget Maphoto, Kershnee Sevnarayan, Ntshimane Elphas Mohale, Zuleika Suliman, Tumelo Jacquiline Ntsopi, Douglas Mokoena   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Struggling with generative AI: Digital self-determination along infrastructures of automation

communication +1
The widespread adoption of generative artificial intelligence (AI) has led to struggles on a global scale by individual and collective actors trying to secure their autonomy with reference to generative AI. There are several examples of how generative AI
Anne Mollen
doaj   +2 more sources