Results 41 to 50 of about 318,460 (275)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Influence of AI literacy and 21st-century skills on the acceptance of generative artificial intelligence among college students

open access: yesFrontiers in Education
IntroductionFostering Artificial Intelligence (AI) literacy and equipping college students with 21st-century skills in the generative AI era have become a global educational priority. In this context, generative AI offers opportunities for development in
Reham Salhab, Mosab M. Aboushi
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Telaah Metode Pembelajaran Perancangan: Eksplorasi Desain Instalasi dengan Penerapan Generative AI

open access: yesArsitekno
Pelibatan generative AI ke dalam proses merancang arsitektur sudah banyak dilakukan. Berbagai studi juga telah dilakukan untuk menelaah penerapan generative AI di dalam proses pembelajaran arsitektur namun dalam konteks Indonesia belum banyak dipaparkan
Adriyan Kusuma
doaj   +1 more source

Nonparametric Nearest Neighbor Random Process Clustering

open access: yes, 2015
We consider the problem of clustering noisy finite-length observations of stationary ergodic random processes according to their nonparametric generative models without prior knowledge of the model statistics and the number of generative models.
Bölcskei, Helmut, Tschannen, Michael
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Effects of generative artificial intelligence on cognitive effort and task performance: study protocol for a randomized controlled experiment among college students

open access: yesTrials
Background The advancement of generative artificial intelligence (AI) has shown great potential to enhance productivity in many cognitive tasks. However, concerns are raised that the use of generative AI may erode human cognition due to over-reliance ...
Youjie Chen   +12 more
doaj   +1 more source

Generative Artificial Intelligence in Education: Advancing Adaptive and Personalized Learning

open access: yesActa Informatica Pragensia
The integration of generative artificial intelligence (AI) into adaptive and personalized learning represents a transformative shift in the educational landscape.
Manel Guettala   +3 more
doaj   +1 more source

Effective Inference for Generative Neural Parsing

open access: yes, 2017
Generative neural models have recently achieved state-of-the-art results for constituency parsing. However, without a feasible search procedure, their use has so far been limited to reranking the output of external parsers in which decoding is more ...
Fried, Daniel   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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