Results 41 to 50 of about 1,202,889 (305)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Effects of generative artificial intelligence on cognitive effort and task performance: study protocol for a randomized controlled experiment among college students

Trials
Background The advancement of generative artificial intelligence (AI) has shown great potential to enhance productivity in many cognitive tasks. However, concerns are raised that the use of generative AI may erode human cognition due to over-reliance ...
Youjie Chen, Yingying Wang, Torsten Wüstenberg, Rene F. Kizilcec, Yiwen Fan, Yanfei Li, Bin Lu, Meng Yuan, Junlai Zhang, Ziyue Zhang, Pascal Geldsetzer, Simiao Chen, Till Bärnighausen   +12 more
doaj   +1 more source

Generative Artificial Intelligence in Education: Advancing Adaptive and Personalized Learning

Acta Informatica Pragensia
The integration of generative artificial intelligence (AI) into adaptive and personalized learning represents a transformative shift in the educational landscape.
Manel Guettala, Samir Bourekkache, Okba Kazar, Saad Harous   +3 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Proses Adopsi Teknologi Generative Artificial Intelligence dalam Dunia Pendidikan: Perspektif Teori Difusi Inovasi

Jurnal Pendidikan dan Kebudayaan
Penelitian ini bertujuan menganalisis proses yang dapat dilakukan dalam adopsi teknologi generative artificial Intelligence (AI) melalui perspektif teori difusi inovasi sehingga dapat memaksimalkan kebermanfaatannya.
Shiddiq Sugiono
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Connecting dreams with visual brainstorming instruction

Visual Intelligence
Recent breakthroughs in understanding the human brain have revealed its impressive ability to efficiently process and interpret human thoughts, opening up the possibility of intervening in brain signals. In this paper, we aim to develop a straightforward
Yasheng Sun, Bohan Li, Mingchen Zhuge, Deng-Ping Fan, Salman Khan, Fahad Shahbaz Khan, Hideki Koike   +6 more
doaj   +1 more source

Preparing teachers for the algorithmic educational landscape: A critical mapping of generative AI integration in language teacher education

Technology in Language Teaching & Learning
The increasing integration of generative Artificial Intelligence (AI) tools, such as ChatGPT, in education has prompted growing interest in their pedagogical potential and the emergent competencies required for their effective use in language ...
Kadir Karakaya, Muhammet Furkan Alpat, Hasan Uçar, Özlem Karakaya, Aras Bozkurt   +4 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source