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Strategic Policies to Support the Independence and Interaction of Older Adults: A Leadership Model That Is Inclusive of Local Businesses [PDF]

open access: yesBusiness Ethics and Leadership, 2023
This study employs qualitative analysis techniques for text mining, and its primary focus is on interview data collected from 105 elderly residents living in Mihama City, Fukui Prefecture.
Hiroko Oe   +6 more
doaj   +1 more source

UHPLC-ESI-QE-Orbitrap-MS based metabolomics reveals the antioxidant mechanism of icaritin on mice with cerebral ischemic reperfusion [PDF]

open access: yesPeerJ, 2023
Background Icaritin (ICT) has been previously demonstrated to display protective effects against cerebral ischemic reperfusion (I/R) by inhibiting oxidative stress, but the mechanism remains unclear.
Yunfeng Tang   +7 more
doaj   +2 more sources

Design and implementation of semi-physical simulation system based on generic interface adapter [PDF]

open access: yesZhihui kongzhi yu fangzhen, 2023
Aiming at the application requirements of the semi-physical simulation environment of the generic interface in the aviation field, on the basis of the construction of the virtual integration and simulation verification platform, the construction method ...
LI Yang, WANG Chuang, TIAN Lirong, ZOU Fanglin
doaj   +1 more source

The anti-aging effects of Renshen Guben on thyrotoxicosis mice: Improving immunosenescence, hypoproteinemia, lipotoxicity, and intestinal flora

open access: yesFrontiers in Immunology, 2022
With the rapid aging of the population, the control of age-related disease susceptibility and prognosis faces greater challenges. There is an urgent need for a strategy to maintain the vitality of elderly people.
Qin Feng   +7 more
doaj   +1 more source

Jingfang Granules alleviate LPS-induced mastitis by inhibiting inflammation, protecting the blood-milk barrier structure and regulating cell apoptosis

open access: yesPharmacological Research - Modern Chinese Medicine, 2022
Mastitis is the most common malignant disease in women, which seriously threatens women's physical and mental health. Jingfang Granules (JF) is a Chinese medicine compound, derived from the classic famous prescription-''Jingfang Baidu Powder''.
ShiRong Li   +10 more
doaj   +1 more source

Perception of generic drugs among residents in a district of Peru [PDF]

open access: yesJournal of Pharmacy & Pharmacognosy Research, 2023
Context: In the Peruvian context, generic drugs are those pharmaceutical products whose names correspond to the active ingredient of the drug and are not identified by a brand name; brand name drugs, on the other hand, are pharmaceutical products whose ...
Ambrocio Teodoro Esteves Pairazaman   +4 more
doaj   +1 more source

Quantitative methods and modeling to assess COVID‐19‐interrupted in vivo pharmacokinetic bioequivalence studies with two reference batches

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2022
The coronavirus disease 2019 (COVID‐19) has presented unprecedented challenges to the generic drug development, including interruptions in bioequivalence (BE) studies.
Yuqing Gong   +12 more
doaj   +1 more source

MS/MS-Based Molecular Networking: An Efficient Approach for Natural Products Dereplication

open access: yesMolecules, 2022
Natural products (NPs) have historically played a primary role in the discovery of small-molecule drugs. However, due to the advent of other methodologies and the drawbacks of NPs, the pharmaceutical industry has largely declined in interest regarding ...
Guo-Fei Qin   +9 more
doaj   +1 more source

Particle size affects pharmacokinetics of milled oxycodone hydrochloride tablet products following nasal insufflation in nondependent, recreational opioid users

open access: yesClinical and Translational Science, 2021
This study assessed the impact of product particle sizes (fine: 106–500 µm; coarse: 500–1000 µm) on oxycodone pharmacokinetics (PK) following nasal insufflation of milled oxycodone extended‐release (ER) abuse‐deterrent (AD) tablets using immediate ...
Saeid Raofi   +11 more
doaj   +1 more source

A polyoxyethylene sorbitan oleate modified hollow gold nanoparticle system to escape macrophage phagocytosis designed for triple combination lung cancer therapy via LDL-R mediated endocytosis

open access: yesDrug Delivery, 2020
Presently, a combination of chemotherapy, radiotherapy, thermotherapy, and other treatments has become a hot topic of research for the treatment of cancer, especially lung cancer.
Yan Shen   +7 more
doaj   +1 more source

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