Results 191 to 200 of about 1,135,224 (358)

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

From body hulls to musculoskeletal models: Personalized inertial parameter estimation. [PDF]

PLoS One
Gambietz M, Azam PQ, Amon P, Wechsler I, Hille EM, Menzel T, Ott T, Botsch M, Braun M, Miehling J, McMahon KL, Koelewijn AD.   +11 more
europepmc   +1 more source

Agricultural Market Structure, Generic Advertising, and Welfare

This analysis begins with a definition and discussion of productive advertising. Then, following Dixit and Norman, persuasive advertising is used to study the welfare effects of generic advertising by marketing orders. The study first examines horizontal
Cardon, James H., Pope, Rulon D.
core  

Regulation, generic competition and pharmaceutical prices: Theory and evidence from a natural experiment [PDF]

We study the impact of regulatory regimes on generic competition and pharmaceutical pricing using a unique policy experiment in Norway, where reference pricing (RP) replaced price cap regulation in 2003 for a sub-sample of off-patent products. We exploit
Odd Rune Straume, Tor Helge Holmås, Kurt R. Brekke   +2 more
core  

Photonic Time Crystals and Time‐Varying Electromagnetic Metamatter: A New Direction for Ultrafast Tunable Photonic and Microwave Materials and Devices

Advanced Science, EarlyView.
Photonic time crystals (PTCs) are systems in which electromagnetic parameters are modulated periodically in time, producing momentum bandgaps via temporal scattering rather than spatial Bragg processes. This review examines the theoretical frameworks, modeling, and computational tools for time‐varying media, and summarizes experimental demonstrations ...
Ranjan Kumar Patel, Shriram Ramanathan, Ronald P. Jenkins, Michael J. Carter   +3 more
wiley   +1 more source

Accelerating Subcutaneous Drug Development: A Mechanistic Absorption Model for the Open Systems Pharmacology Framework. [PDF]

CPT Pharmacometrics Syst Pharmacol
Pellowe M, Dubbelboer I, Sjögren E.
europepmc   +1 more source

A study on influencers of total sales revenue of generic pharmaceutical companies in Indonesia

This paper empirically examines the influence of firms’ one-year lagged of total new products (t-1), one-year lagged profitability (t-1), and market share of new products to firms’ amount of sales revenue in pharmaceutical generic companies in Indonesia.
Tjandrawinata, Raymond R., Simanjuntak, Destrina Grace   +1 more
core  

A generic framework for hybrid simulation in healthcare

, 2010
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 11/01/2010.Healthcare problems are complex; they exhibit both detail and dynamic complexity.
Chahal, Kirandeep
core  

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Availability and Cost of Naloxone Over Time: A Longitudinal Secret Shopper Study in North Carolina Community Pharmacies. [PDF]

J Am Pharm Assoc (2003)
Johnson JM, Marley GT, Annis IE, Carpenter DM.   +3 more
europepmc   +1 more source