Results 191 to 200 of about 828,807 (306)

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

Advanced Science, EarlyView.
Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi, Nicolas Carvalho, Jacinthe Frangieh, Corentin Léger, Dorothée Raoux‐Barbot, J. Iñaki Guijarro, Daniel Ladant, Sophie Cribier, Nicolas Rodriguez, Alexandre Chenal   +9 more
wiley   +1 more source

Utilization, cost, and specialty distribution of topical ruxolitinib prescribing in Medicare Part D, 2018-2024: A cross-sectional study. [PDF]

JAAD Int
Kent JA, Malave GS, Sacknovitz Y, Geskin LJ.   +3 more
europepmc   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

Generic versus branded tigecycline for multidrug-resistant gram-negative bacilli and nontuberculous mycobacterial infections: A comparative safety and efficacy analysis. [PDF]

Medicine (Baltimore)
Sirijatuphat R, Sathienluckana S, Suputtamongkol Y.   +2 more
europepmc   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Towards meaningful outcome measures for health economic evaluations in skin cancer : A decision matrix to guide transparent outcome selection in skin cancer health economic evaluations, supporting more informed decision-making. [PDF]

Cost Eff Resour Alloc
Meertens A, Annemans L, Verstraete F, Hoorens I, Verhaeghe N.   +4 more
europepmc   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Five-year changes in generic and disease-specific patient-reported outcome measures in stable COPD: a real-world cohort study. [PDF]

Patient Relat Outcome Meas
Nishimura K, Kusunose M, Shibayama A, Nakayasu K.   +3 more
europepmc   +1 more source

Architecting Phase‐Selective Interlayers for Stable SiOx Lithium Storage via Dual‐Function Design

Advanced Science, EarlyView.
Silicon anodes offer high capacity but suffer severe volume expansion. Silicon monoxide (SiO) buffers expansion, yet uncontrolled lithiation irreversibly consumes lithium as Li2O and oxygen‐rich silicates. Here, we design a layered SiOx featuring a phase‐selective conductive interfacial interlayer (PSCII), i.e., a Li4SiO4‐rich, ion‐accessible ...
Zhenfei Chang, Wei Dong, Yingguang Zhang, Hangchen Qu, Yifei Wang, Xiaolong Zhao, Chu Wang, Ming Dong, Huizhi Wang, Jin Xuan, Yug Joshi, Dennis Y.C. Leung, Wending Pan   +12 more
wiley   +1 more source

Generic GLP-1 receptor agonists in India: an opportunity to close the cardiovascular evidence gap. [PDF]

Lancet Reg Health Southeast Asia
Monjur MR, Alam A.
europepmc   +1 more source