Results 211 to 220 of about 828,807 (306)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Impact of China's National Volume-Based Procurement Policy on Cost, Volume, and Market Structure: An Interrupted Time-Series Analysis of Montelukast Sodium. [PDF]

Health Care Sci
Cheng Y, Liu F, Wu Y, Liu S, Fan X, Jiang B, Yang Z.   +6 more
europepmc   +1 more source

Insights Into the Nature of Quantum Emitters in Electron‐Irradiated Hexagonal Boron Nitride

Advanced Science, EarlyView.
Hyperspectral imaging is used to identify quantum emitters hosted by the 2D material hexagonal boron nitride. By selecting specific emission wavelengths, one can distinguish individual emitters from ensembles and gain important insights into the atomic structure of these emitters.
Mouli Hazra, Anna Rupp, Mohammad N. Mishuk, Josefine Krause, Anand Kumar, Julien Chénedé, Mingi Kang, Bayarjargal N. Tugchin, Marijn Rikers, Isabelle Staude, Thomas Pertsch, Alexander Högele, Tobias Vogl   +12 more
wiley   +1 more source

Influence of generic drug supply restrictions on quetiapine tablet dispensing ratio and medication costs in community pharmacies in Japan. [PDF]

BMC Health Serv Res
Mukai E, Kondo Y, Kondo T, Okada N, Miura A, Kubota K, Azuma H, Yamakado S, Ishitsuka Y.   +8 more
europepmc   +1 more source

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Investigating the Impact of Food Induced Fluid Viscosity on Disintegration and Dissolution of Immediate Release Midodrine HCl Tablet. [PDF]

AAPS J
Doole FT, Don RW, Poudel I, Lex T, Cheng YH, Wu F, Sun WJ, Zhang L, Langguth P, Jiang W, Gao Z.   +10 more
europepmc   +1 more source

Deep‐Learning‐Based Denoising for Improved Phase Precision in Electron Holography of Electromagnetic Fields in Nanoscale Materials

Advanced Science, EarlyView.
Low‐dose electron holography is limited by shot noise, which buries weak phase signals. HoloDenoiser, a physics‐informed network that works simultaneously in the spatial and frequency domains, locates and protects the holographic sideband while suppressing noise in the hologram.
Ye Luo, Luyang Wang, Zhiling Yu, Xiaowen Chen, Xiaoyu Wang, Ya‐Hui Jia, Thibaud Denneulin, Yu Han, Rafal E. Dunin‐Borkowski, Fengshan Zheng, Qi Liu   +10 more
wiley   +1 more source

Trends in Medicines Discontinuation and Implications for Access in Brazil (2014-2024). [PDF]

Pharmacoepidemiol Drug Saf
de Lima ROM, Silva ER, Emmerick ICM, de Souza Serio Dos Santos DM, Godói IPD, Campos ACV, Chaves LA.   +6 more
europepmc   +1 more source

Emergent Magnetism, Heavy Electrons, and Pressure‐Induced Reentrant Superconductivity in the Iron Substituted 4d Transition‐Metal Sulfides

Advanced Science, EarlyView.
This work illustrates that magnetic Fe substitution enables systematic modulation of physical properties of the putative unconventional superconductor Rh17S15. Iron doping uncovers delicate competition between weak ferromagnetism, spin‐glass states, heavy‐fermion signatures, and superconductivity.
Yalei Huang, Lu Xin, Na Zuo, Bin Li, Wei Zhou, Dhanarajagopal Alltrin, Boning Yu, Haiyang Yang, Bin Qian, Wen‐Chin Lin, Raman Sankar, Michael Smidman, Xiangzhuo Xing, Chunqiang Xu, Xiaobing Liu, Jianhui Dai, Dong Qian, Shiyan Li, Xiaofeng Xu   +18 more
wiley   +1 more source