Results 71 to 80 of about 276,945 (256)
Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes
Advanced Science, EarlyView.This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin +2 more
wiley +1 more source
Advanced Science, EarlyView.Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou +6 more
wiley +1 more source
Advanced Science, EarlyView.We generated multi‐tissue single‐cell transcriptomic atlases of camels and cattle, uncovering conserved and lineage‐specific cellular features across digestive and metabolic systems. Cross‐species comparisons revealed the evolutionary origin of the camel glandular sac and identified novel cell populations linked to physiological specialization ...
Tao Shi +22 more
wiley +1 more source
Do generic drugs cause hypersensitivity? [PDF]
Eur J Dermatol, 2022 Tetart F, Gonde H, Hervouët C.
europepmc +1 more source
Generics and New Goods in Pharmaceutical Price Indexes [PDF]
We examine the issue of new goods and price indexes for the important and tractable case of generic and branded drugs. By treating generics as entirely distinct goods and "linking them in" to indexes with fixed weights, the standard price indexes fail to
Iain Cockburn, Zvi Griliches
core
Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome
Advanced Science, EarlyView.By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang +12 more
wiley +1 more source
A comparative study on perception and use of generic drugs between public and private health practitioners. [PDF]
J Family Med Prim Care, 2023 Priyadarsini R +3 more
europepmc +1 more source
Advanced Science, EarlyView.In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei +17 more
wiley +1 more source
Is It Possible to Have Cheaper Drugs and Preserve the Incentive to Innovate: Reforming the Drug Approval Process According to Market Principles [PDF]
This paper argues that drugs are expensive not because of a lack of competition among research-based pharmaceutical companies, but because of a lack of competition in the drug approval process.
Corinne Sauer, Robert Sauer
core