Results 91 to 100 of about 2,104,479 (293)

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Description of hardware configurations of guest systems in QEMU emulator as separate text files

Труды Института системного программирования РАН, 2018
QEMU is an open-source full system emulator based on the dynamic binary translation approach. QEMU emulates a complete hardware environment including CPUs, peripheral devices (VGA cards, network interfaces, IDE controllers, sound and USB components, and ...
O. V. Goremykin
doaj   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Model-Integrated Bioequivalence (MIBE) in Generic Drug Research: Can We Ease the Bioequivalence Burden?

Pharmaceutics
Bioequivalence (BE) studies are essential to file an abbreviated new drug application (ANDA) against an innovator drug product. Conventional BE studies can be complex, time-consuming, and operationally challenging, particularly for products with long ...
Sivacharan Kollipara, Rajkumar Boddu, Chandra Teja Uppuluri, Anuj Kumar Saini   +3 more
doaj   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Implementasi FTP Server dengan Metode Transfer Layer Security untuk Keamanan Transfer Data Menggunakan CentOS 5.8 [PDF]

, 2014
Dalam kehidupan sehari-hari pertukaran informasi sangatlah dibutuhkan, untuk mendapatkan informasi atau bertukar informasi dapat dilakukan kapan saja dan dimana saja.
Oklilas, Ahmad Fali, Irawan, Budi
core   +1 more source

Progressive Syntax-Rich Coding of Multichannel Audio Sources

EURASIP Journal on Advances in Signal Processing, 2003
Being able to transmit the audio bitstream progressively is a highly desirable property for network transmission. MPEG- version audio supports fine grain bit rate scalability in the generic audio coder (GAC).
Yang Dai, Ai Hongmei, Kyriakakis Chris, Kuo C-C Jay   +3 more
doaj   +1 more source

Energy-Efficient Integration of Continuous Context Sensing and Prediction into Smartwatches

Sensors, 2015
As the availability and use of wearables increases, they are becoming a promising platform for context sensing and context analysis. Smartwatches are a particularly interesting platform for this purpose, as they offer salient advantages, such as their ...
Reza Rawassizadeh, Martin Tomitsch, Manouchehr Nourizadeh, Elaheh Momeni, Aaron Peery, Liudmila Ulanova, Michael Pazzani   +6 more
doaj   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source