Results 51 to 60 of about 480,989 (325)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Médicaments génériques : pivot de la reconstruction de l’industrie pharmaceutique

Revue de la Régulation, 2015
The pharma has a particular significance given the challenges it involves for public health, economics, politics and ethics. The medicines production is therefore subject to multiple and complex regulations, both national and international. While some of
Philippe Abecassis, Nathalie Coutinet
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Generics and Context: Do Counterexamples Dissuade Acceptance of True Generic Statements?

Studies in Logic, Grammar and Rhetoric
This study investigates whether the salience of counterexamples in discourse affects the acceptance of true generic statements. Building on previous theoretical and experimental work on generics, we examine whether generics are sensitive to contextual ...
Wajda Edyta, Karczewski Daniel
doaj   +1 more source

Generics versus branded generics: A case of confusion

Indian Journal of Community and Family Medicine
Generic medicines are generally marketed under international nonproprietary names but may also be marketed by a pharmaceutical company under a brand name, i.e. branded generics.
Proteesh Rana, Rachna Gupta
doaj   +1 more source

Multiple policies to enhance prescribing efficiency for established medicines in Europe with a particular focus on demand-side measures: findings and future implications

Frontiers in Pharmacology, 2014
Introduction: The appreciable growth in pharmaceutical expenditure has resulted in multiple initiatives across Europe to lower generic prices and enhance their utilisation. However, considerable variation in their use and prices.
Brian eGodman, Brian eGodman, Brian eGodman, Bjorn eWettermark, Bjorn eWettermark, Bjorn eWettermark, Menno eVan Woerkom, Jessica eFraeyman, Samantha eAlvarez-Madrazo, Christian eBerg, Iain eBishop, Anna eBucsics, Stephen eCampbell, Alexander E Finlayson, Jurij eFurst, Kristina eGaruoliene, Kristina eGaruoliene, Harald eHerholz, Marija eKalaba, Ott eLaius, Jutta ePiessnegger, Catherine eSermet, Ulrich eSchwabe, Vera eV Vlahović-Palčevski, Vanda eMarkovic-Pekovic, Vanda eMarkovic-Pekovic, Luka eVoncina, Kamila eMalinowska, Kamila eMalinowska, Corinne eZara, Lars L Gustafsson   +30 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Management of Multiple Myeloma and Usage of Bortezomib: Perspective from India and Ukraine

Frontiers in Oncology, 2016
Novel treatment strategies have remarkably improved the multiple myeloma (MM) patients’ survival, with associated increased costs.A joint panel meet of international experts from India and Ukraine was held in New Delhi on 19th May 2016 focusing on: MM ...
India and Ukraine Haemato-oncology Group, Dharma Choudhary, Dinesh Bhurani, Iryna Kryachok, Iryna Koren’kova, Orest Tsyapka, Rahul Naithani, Viktor Kozlov, Amit Garg, Mykhaylo Morgunskyy, Yogesh Belagali, Namita Gupta, Shyam Prasad Akku   +12 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Introduction [PDF]

, 2012
Introduction to genericity in the nominal, verbal and sentential ...
Beyssade, Claire, Del Prete, Fabio, Mari, Alda   +2 more
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