Results 51 to 60 of about 593,242 (377)

Towards a Java Subtyping Operad

, 2017
The subtyping relation in Java exhibits self-similarity. The self-similarity in Java subtyping is interesting and intricate due to the existence of wildcard types and, accordingly, the existence of three subtyping rules for generic types: covariant ...
Andrew, Cartwright Robert, David, Gosling James, Gosling James, Igarashi Atsushi, Leinster T., Scott Dana S., Spivak David I, Torgersen Mads   +9 more
core   +1 more source

Nocebo in Biosimilars and Generics in Neurology: A Systematic Review

Frontiers in Pharmacology, 2019
Background: Nocebo refers to adverse events related to patients’ negative expectations and previous experiences, mediated by several neurobiological pathways within the brain.
Ioanna Spanou, T. Mavridis, D. Mitsikostas   +2 more
semanticscholar   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Multiple policies to enhance prescribing efficiency for established medicines in Europe with a particular focus on demand-side measures: findings and future implications

Frontiers in Pharmacology, 2014
Introduction: The appreciable growth in pharmaceutical expenditure has resulted in multiple initiatives across Europe to lower generic prices and enhance their utilisation. However, considerable variation in their use and prices.
Brian eGodman, Brian eGodman, Brian eGodman, Bjorn eWettermark, Bjorn eWettermark, Bjorn eWettermark, Menno eVan Woerkom, Jessica eFraeyman, Samantha eAlvarez-Madrazo, Christian eBerg, Iain eBishop, Anna eBucsics, Stephen eCampbell, Alexander E Finlayson, Jurij eFurst, Kristina eGaruoliene, Kristina eGaruoliene, Harald eHerholz, Marija eKalaba, Ott eLaius, Jutta ePiessnegger, Catherine eSermet, Ulrich eSchwabe, Vera eV Vlahović-Palčevski, Vanda eMarkovic-Pekovic, Vanda eMarkovic-Pekovic, Luka eVoncina, Kamila eMalinowska, Kamila eMalinowska, Corinne eZara, Lars L Gustafsson   +30 more
doaj   +1 more source

From Generation to Generation [PDF]

Clinical Chemistry, 2019
This work (Fig. 1) is a geometric abstraction that I created using pencil, ink, and acrylic paint on canvas. It could be interpreted as a spatial representation of time, peering along the branches of a pedigree or phylogenetic tree. The tree consists of three main branches with “cousins” on two of the branches connected by …
openaire   +3 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Management of Multiple Myeloma and Usage of Bortezomib: Perspective from India and Ukraine

Frontiers in Oncology, 2016
Novel treatment strategies have remarkably improved the multiple myeloma (MM) patients’ survival, with associated increased costs.A joint panel meet of international experts from India and Ukraine was held in New Delhi on 19th May 2016 focusing on: MM ...
India and Ukraine Haemato-oncology Group, Dharma Choudhary, Dinesh Bhurani, Iryna Kryachok, Iryna Koren’kova, Orest Tsyapka, Rahul Naithani, Viktor Kozlov, Amit Garg, Mykhaylo Morgunskyy, Yogesh Belagali, Namita Gupta, Shyam Prasad Akku   +12 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Generics and Context: Do Counterexamples Dissuade Acceptance of True Generic Statements?

Studies in Logic, Grammar and Rhetoric
This study investigates whether the salience of counterexamples in discourse affects the acceptance of true generic statements. Building on previous theoretical and experimental work on generics, we examine whether generics are sensitive to contextual ...
Wajda Edyta, Karczewski Daniel
doaj   +1 more source

Generics versus branded generics: A case of confusion

Indian Journal of Community and Family Medicine
Generic medicines are generally marketed under international nonproprietary names but may also be marketed by a pharmaceutical company under a brand name, i.e. branded generics.
Proteesh Rana, Rachna Gupta
doaj   +1 more source