Results 81 to 90 of about 44,727 (269)
Germline BRCA1 and BRCA2 mutations and the risk of bladder or kidney cancer in Poland
Hereditary Cancer in Clinical Practice, 2022 Introduction The role of the BRCA1 and BRCA2 genes in bladder and renal tumorigenesis is unclear. Our goal was to determine the prevalence of specific founder mutations genes BRCA1 (5328 insC, C61G and 4153 delA) and BRCA2 (C5972T) mutations in bladder ...
Elżbieta Złowocka-Perłowska +3 more
doaj +1 more source
iNew Medicine, EarlyView.ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid +4 more
wiley +1 more source
A common SNP in the UNG gene decreases ovarian cancer risk in BRCA2 mutation carriers
Molecular Oncology, 2019 Single nucleotide polymorphisms (SNPs) in DNA glycosylase genes involved in the base excision repair (BER) pathway can modify breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
Juan Miguel Baquero +8 more
doaj +1 more source
, 2013 Footnote. t: moderated t-statistic for 66 genes that best discriminate between BRCA2 and BRCAX tumors. p: p-value after Benjamini Hochberg correction (all genes had an unadjusted p-value
Françoise Bonnet (292500) +13 more
core +1 more source
Genetics of DNA replication and homologous recombination in arabidopsis [PDF]
, 2005 The integrity of genetic information of each cell is constantly subjected to various threats, originating from environmental and endogenous sources.
Schürmann, David
core +1 more source
Genetic analysis of primary lung interdigitating dendritic cell sarcomas
The Journal of Pathology, EarlyView.Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov +6 more
wiley +1 more source
Brca2 is required for embryonic cellular proliferation in the mouse
, 1997 Mutations of the tumor suppressor gene BRCA2 are associated with predisposition to breast and other cancers. Homozygous mutant mice in which exons 10 and 11 of the Brca2 gene were deleted by gene targeting (Brca210-11) die before day 9.5 of embryogenesis.
Nishina, Hiroshi +15 more
core +1 more source
Attitudes Toward Prenatal Interventions in the Fanconi Anemia Community
Prenatal Diagnosis, EarlyView.ABSTRACT Objective In‐utero cell and gene therapies may offer prenatal treatment options for inherited diseases. Preclinical data suggests in‐utero (IU) hematopoietic stem cell transplantation (HSCT) could prevent Fanconi anemia (FA) related bone marrow failure without genotoxic conditioning or immune suppression.
Tony Lum +4 more
wiley +1 more source
Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function.
PLoS Genetics, 2018 The cohesin complex topologically encircles chromosomes and mediates sister chromatid cohesion to ensure accurate chromosome segregation upon cell division. Cohesin also participates in DNA repair and gene transcription. The Nipped-B-Mau2 protein complex
Ziva Misulovin +3 more
doaj +1 more source
Cancer incidence in relatives of British Fanconi Anaemia patients.
, 2008 BACKGROUND: Fanconi anemia (FA) is an autosomal recessive DNA repair disorder with affected individuals having a high risk of developing acute myeloid leukaemia and certain solid tumours. Thirteen complementation groups have been identified and the genes
Ball Jan +14 more
core +1 more source