Results 201 to 210 of about 6,532,899 (237)

Dominant genes for colorectal cancer are not rare

Annals of Human Genetics, 1992
SummaryThe genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0·006 with a lifetime penetrance of 0·63.
Houlston, R. S., Collins, Andrew, Slack, J., Morton, N. E.   +3 more
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Functional inactivation of genes by dominant negative mutations

Nature, 1987
Molecular biologists are increasingly faced with the problem of assigning a function to genes that have been cloned. A new approach to this problem involves the manipulation of the cloned gene to create what are known as 'dominant negative' mutations.
I. Herskowitz
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The Runx genes as dominant oncogenes

Blood Cells, Molecules, and Diseases, 2003
We have shown previously that Runx2 is a frequent target (approximately equal to 30%) for proviral insertion in murine leukemia virus (MLV) induced T cell tumors in CD2-MYC transgenic mice. Further investigation of a large panel of these tumors revealed that a small number also contain insertions at either Runx3 or Runx1.
James C. Neil, Ewan R. Cameron, Nancy Mackay, Sandy Wotton, Monica Stewart, François Vaillant, Karen Blyth, Linda Hanlon, Anne Terry, Anna Kilbey   +9 more
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Connexin 26 gene linked to a dominant deafness [PDF]

Nature, 1998
A high proportion of all cases of congenital deafness is causedby mutations in a gene coding for a gap-junction protein,connexin 26. The deafness associated with this gene, Cx26, is the autosomal recessive form, DFNB1(refs 1–3); its involvement in autosomal dominant forms of deafness has remained controversial4.
Denoyelle, Françoise, Lina-Granade, Genevieve, Plauchu, Henri, Bruzzone, Roberto, Chaïb, Hassan, Levi-Acobas, Fabienne, Weil, Dominique, Petit, Christine   +7 more
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A Dominant Gene for Male Sterility in Wheat

Plant Breeding, 1986
AbstractA dominant gene inducing male sterility in wheat is described. It is located on the short arm of chromosme 4D with a recombination percentage of 31.16 with the centromere. The potential use of this allele in breeding and cytogenetic studies in both tetraploid and hexaploid with is discussed.
D. Jing-Yang, L. Bing-Hua
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Gene-Based Therapies for Dominant Retinopathies

Current Gene Therapy, 2010
Over the past two decades, significant progress has been made in defining the molecular pathogenesis of hereditary retinal degenerations. Many of these are characterised by immense genetic heterogeneity. For example, in retinitis pigmentosa (RP), the most common form of this group of disorders, approximately 50 disease causing genes have been ...
Paul F. Kenna, Mary O'Reilly, Arpad Palfi, G. Jane Farrar   +3 more
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Severe Renal Dysgenesis Produced by a Dominant Gene

Archives of Pediatrics & Adolescent Medicine, 1976
A woman with the autosomal dominant syndrome of preauricular pits, cervical fistulae, and partial deafness gave birth to two children with preauricular pits and severe renal dysgenesis. The facies had some features of the Potter facies of renal agenesis. One child died soon after birth because of pneumothorax and immature development of the lungs.
Naomi Fitch, Herbert Srolovitz
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A dominant gene for yellow fruit in the raspberry

Euphytica, 1975
A gene for yellow fruit, designated Y, segregated in progenies obtained by crossing R. phoenicolasius with the red raspberry and backcrossing to the raspberry. Another gene, designated Ys, suppressed its expression in R. phoenicolasius itself and in the F1.
Eleanor Carmichael, D. L. Jennings
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Melanin inhibitor: a dominant gene in the domestic cat

Journal of Heredity, 1980
Melanin inhibitor (symbol I) is shown to be inherited as a dominant to the wild type and independent of the albino locus. The gene inhibits the formation of melanin in the less intensely pigmented regions of the coat, namely, the agouti areas between the tabby pattern and the proximal portion of the hair.
Patricia Turner, Roy Robinson
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A Dominant Gene for Renal Adenomas in the Rat

Nature, 1961
FAMILIAL renal adenomas in the rat have been described in a previous report1. They usually occurred as multiple tumours and were bilateral. The tumours were simple cysts, papillary cystadenomas, solid eosinophile adenomas or solid basophile tubular adenomas.
Reidar Eker, Jeanne Mossige
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