Results 271 to 280 of about 911,821 (309)
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VH‐Gene Family Dominance in Ageing Mice
Scandinavian Journal of Immunology, 1994The cellular composition and Vn‐gene family repertoire were compared in different B‐cell compartments from young adult (8–12 weeks) and old (18–24 months) C57BL/6 and BALB/c mice. Ageing mice were found to have a higher frequency of peripheral mature B cells utilizing genes from a single VH‐gene family.
A C, Viale +6 more
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Functional dominance among Hox genes: repression dominates activation in the regulation of dpp
Development, 1998ABSTRACT Here we investigate the mechanisms by which Hox genes compete for the control of positional identity. Functional dominance is often observed where different Hox genes are co-expressed, and frequently the more posteriorly expressed Hox gene is the one that prevails, a phenomenon known as posterior prevalence.
Capovilla, Maria, Botas, J
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Gene therapeutic approaches for dominant retinopathies.
Current gene therapy, 2011Over the past two decades, significant progress has been made in defining the molecular pathogenesis of hereditary retinal degenerations. Many of these are characterised by immense genetic heterogeneity. For example, in retinitis pigmentosa (RP), the most common form of this group of disorders, over 50 disease causing genes have been implicated, 20 of ...
G Jane, Farrar +2 more
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Functional inactivation of genes by dominant negative mutations
Nature, 1987Molecular biologists are increasingly faced with the problem of assigning a function to genes that have been cloned. A new approach to this problem involves the manipulation of the cloned gene to create what are known as 'dominant negative' mutations.
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Gene expression and parental dominance in hybrid plants
Development, 1990ABSTRACT Genomic imprinting, where the genes from one parent have different expression properties to those of the other parent, occurs in plants. It has potentially significant consequences because of the importance of hybrids in plant evolution and plant breeding, and provides a mechanism that can hide genetic variation for many ...
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Maximum Rate of Selection for Dominant Quantitative Genes
Nature, 1946THE following formulae are proposed to measure the maximum rate of progress of selection for dominant quantitative genes. To simplify the problem, certain assumptions are made: (1) Selection begins in the F2 generation of a cross between two pure lines. (2) All genes are dominant in the positive direction.
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LRRK2 Gene and Tremor-Dominant Parkinsonism
Archives of Neurology, 2006Kristoffer, Haugarvoll +3 more
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RNAi therapy: Dominant disease gene gets silenced
Gene Therapy, 2005Z, Xu, X G, Xia
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Heterologous expression for dominant-like gene activity
Trends in Plant Science, 2000A, Diener, H, Hirschi
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