Results 271 to 280 of about 548,379 (312)

Connexin 26 gene linked to a dominant deafness

Nature, 1998
A high proportion of all cases of congenital deafness is causedby mutations in a gene coding for a gap-junction protein,connexin 26. The deafness associated with this gene, Cx26, is the autosomal recessive form, DFNB1(refs 1–3); its involvement in autosomal dominant forms of deafness has remained controversial4.
Denoyelle, Françoise, Lina-Granade, Genevieve, Plauchu, Henri, Bruzzone, Roberto, Chaïb, Hassan, Levi-Acobas, Fabienne, Weil, Dominique, Petit, Christine   +7 more
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Genetic mechanisms for dominant VH gene expression. The VHB512 gene

The Journal of Immunology, 1992
Abstract A total of 37 mAb with reactivity for dextran B512 have been studied; 30 of them were products of independent rearrangements and 21 made use of the same VH gene, the VHB512 gene. These results unambiguously established that the immune response to dextran in the high responder mouse strain C57BL/6 was restricted.
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Genomewide association for a dominant pigmentation gene in sheep

Journal of Animal Breeding and Genetics, 2013
SummaryMost published genomewide association studies (GWAS) in sheep have investigated recessively inherited monogenic traits. The objective here was to assess the feasibility of performing GWAS for a dominant trait for which the genetic basis was already known.
Kijas, James, Serrano Noreña, Magdalena, McCulloch, R., Li, Y., Salces-Ortiz, Judit, Calvo, Jorge Hugo, Pérez-Guzmán, M. D.   +6 more
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Functional inactivation of genes by dominant negative mutations

Nature, 1987
Molecular biologists are increasingly faced with the problem of assigning a function to genes that have been cloned. A new approach to this problem involves the manipulation of the cloned gene to create what are known as 'dominant negative' mutations.
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Testing for the presence of a partially penetrant dominant gene

Mutation Research Letters, 1983
Favor, in the Appendix to a paper by Ehling and his collaborators (Ehling et al., 1982), develops a method that tests for the presence of a partially penetrant dominant cataract mutation in a suspected parent (showing lens opacity) outcrossed to a homozygous strain-101 mouse when no individual with lens opacity is observed in the progeny.
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Polyoma tumorigenesis in mice: Evidence for dominant resistance and dominant susceptibility genes of the host

Virology, 1992
We have determined the tumor responses of nine inbred mouse strains and of two F1 hybrids following inoculation with polyoma virus. The results showed wide variations in the frequencies of mice developing tumors. Correlation with H-2 haplotype were evident.
R, Freund, T, Dubensky, R, Bronson, A, Sotnikov, J, Carroll, T, Benjamin   +5 more
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The evolution of plasmodial stage-specific rRNA genes is dominated by gene conversion

Journal of Molecular Evolution, 1991
Plasmodium species exhibit the unprecedented situation of distinct, stage-specific rRNA sequences. We present an analysis of two pairs of sequences of the small rRNA subunit (Plasmodium falciparum and Plasmodium berghei) and show that these genes do not evolve independently and that in fact their evolution is dominated by gene conversion. This analysis
V, Enea, V, Corredor
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Gene expression and parental dominance in hybrid plants

Development, 1990
ABSTRACT Genomic imprinting, where the genes from one parent have different expression properties to those of the other parent, occurs in plants. It has potentially significant consequences because of the importance of hybrids in plant evolution and plant breeding, and provides a mechanism that can hide genetic variation for many ...
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Gene dosage balance: deletions, duplications and dominance

Trends in Genetics, 2005
The number of known human genes whose heterozygous null alleles lead to disease (i.e. haploinsufficient genes) is increasing. A recent update shows that they encode preferentially structural proteins, transcription regulators, signal transduction elements and various binding factors [1].
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On survival probabilities of mutant genes and the evolution of dominance

Theoretical Population Biology, 1976
Abstract Intrinsic biological resemblance between two types is measured in terms of a correlation between their fitnesses under various possible environmental conditions. A tendency toward dominance is defined as the intrinsic biological resemblance between homozygote and heterozygote.
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