Results 71 to 80 of about 548,379 (312)
Power curves as a function of sample sizes under Dominant OR Dominant with two genes including rare variants only. [PDF]
, 2016 Power curves as a function of sample sizes under Dominant OR Dominant with two genes including rare variants only.
Meimei Liang (405625) +3 more
core +1 more source
BMC Bioinformatics, 2008 Background The Signal-to-Noise-Ratio (SNR) is often used for identification of biomarkers for two-class problems and no formal and useful generalization of SNR is available for multiclass problems.
Chung I-Fang +4 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Mutation-independent treatment of autosomal dominant Retinitis Pigmentosa (adRP) [PDF]
, 2010 Viral-mediated gene therapy holds great promise for the treatment of severe inherited retinal diseases, such as Retintitis Pigmentosa (RP), which is caused by mutations in genes preferentially expressed in photoreceptor cells. The availability of vectors
Mussolino, Claudio
core
MicroorganismsHenan mung bean sour (HMBS) is the raw material for mung bean sour noodles (MBSNs), a traditional fermented food. To investigate the characteristic flavor compounds, we have detected the content of free amino acids (FAAs) and key metabolites including ...
Xunda Wang +5 more
doaj +1 more source
An Introduction of Dominant Genes in Genetic Algorithm for Scheduling of FMS [PDF]
Proceedings of the 2005 IEEE International Symposium on, Mediterrean Conference on Control and Automation Intelligent Control, 2005., 2005 This paper proposed a new idea named dominant genes (DGs) in genetic algorithms (GAs) to deal with FMS scheduling problem with alternative production routing. In traditional GAs approach, the crossover mechanism will randomly select a number of genes to undergo crossover.
Felix T. S. Chan +2 more
openaire +2 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Specific Resistance Genes in Wheat Chinese Landrace ‘Wangshuibai’ against Two Iranian Mycosphaerella Graminicola Isolates [PDF]
, 2010 Septoria tritici blotch, caused by the fungus Mycosphaerella graminicola, is currently the major foliar disease of wheat world-wide, and new sources of resistance and knowledge about the genetics of resistance are needed to improve breeding for ...
Pardis, M.E. +8 more
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source