Results 101 to 110 of about 5,097,692 (293)
Advanced Science, EarlyView.This study develops a strategy to screen the active compounds from bio‐mixtures via combining transcriptomic profiling and molecular docking. The proposed method demonstrates 100% correction in three different biobased mixtures and is 3–20 times faster than traditional approaches.
Yongdong Xu +8 more
wiley +1 more source
Pan-genome analyses of model fungal species
Microbial Genomics, 2019 The concept of the species ‘pan-genome’, the union of ‘core’ conserved genes and all ‘accessory’ non-conserved genes across all strains of a species, was first proposed in prokaryotes to account for intraspecific variability.
Charley G. P. McCarthy, D. Fitzpatrick
semanticscholar +1 more source
Advanced Science, EarlyView.Carbon dots (CDs) are incorporated into ZIF‐8 to synthesize CDs@ZIF‐8 nanocomposites, which exhibit dual photodynamic enhanced antimicrobial properties. This enhancement is due to the narrow bandgap of CDs@ZIF‐8, which facilitates interfacial electronic transfer, resulting in increased reactive oxygen species. Microfluidic blow spinning is then used to
Yongrui Ti +10 more
wiley +1 more source
Comparative genomics reveals the origin of fungal hyphae and multicellularity
Nature Communications, 2019 Hyphae represent a hallmark structure of multicellular fungi. The evolutionary origins of hyphae and of the underlying genes are, however, hardly known.
E. Kiss +12 more
semanticscholar +1 more source
A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues
Advanced Science, EarlyView.Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan +12 more
wiley +1 more source
Advanced Science, EarlyView.The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song +13 more
wiley +1 more source
mSphereThe regulation of fungal cell wall biosynthesis is crucial for cell wall integrity maintenance and directly impacts fungal pathogen virulence. Although numerous genes are involved in fungal cell wall polysaccharide biosynthesis through multiple pathways,
Yuan Chen +5 more
doaj +1 more source
Frontiers in Chemistry, 2015 Fusarium oxysporum is a devastating pathogen causing extensive yield losses in a variety of crops and development of sustainable, environmentally friendly methods to improve crop resistance is crucial. We have used Host-Derived RNA interference (HD-RNAi)
Zongli eHu +5 more
doaj +1 more source
Advanced Science, EarlyView.L14‐8, a small molecule derived from the marketed drug ezetimibe, potently inhibits advanced prostate cancer independent of androgen receptor signaling. L14‐8 binds PLK1, triggering its ubiquitin‐mediated degradation. This activates TP53‐dependent transcription of SAT1, inducing ferroptosis and suppressing tumor growth in prostate cancer patient ...
Yu Zhang +8 more
wiley +1 more source
Frontiers in Plant Science, 2017 During infection, pathogens secrete an arsenal of molecules, collectively called effectors, key elements of pathogenesis which modulate innate immunity of the plant and facilitate infection.
Yohann Petit-Houdenot, Isabelle Fudal
doaj +1 more source