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Fungal Gene-Encoded Peptidase Inhibitors
Current Medicinal Chemistry, 2013Peptidases can be inhibited by natural or synthetic small-molecule compounds, or by gene-encoded, proteinaceous inhibitors. Small-molecule peptidase inhibitors have been in the spotlight of researchers and pharmaceutical companies for many years. The studies concerning gene-encoded inhibitors are less frequent. The last decade has seen a boom of fungal
V, Bauerová +2 more
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Chitotriosidase and gene therapy for fungal infections
Cellular and Molecular Life Sciences, 2009Chitotriosidase secreted by activated human macrophages has been implicated in the defence against chitin-bearing pathogens. The antifungal properties of human chitotriosidase were investigated here following retroviral vector-mediated gene transfer of the open reading frame of the chitotriosidase gene into Chinese hamster ovary cells.
Gordon-Thomson, Clare (R8937) +7 more
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Acquisition of prokaryotic genes by fungal genomes
Trends in Genetics, 2010The relevance of horizontal gene transfer (HGT) in eukaryotes is a matter of debate. Recent analyses have shown clear examples in some species such as Candida parapsilosis, but broader surveys are lacking. To assess the impact of HGT in the fungal kingdom, we searched for prokaryotic-derived HGTs in 60 fully sequenced genomes. Using strict phylogenomic
Marina, Marcet-Houben, Toni, Gabaldón
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Plant genes hijacked by necrotrophic fungal pathogens
Current Opinion in Plant Biology, 2020Plant fungal pathogens can be classified according to their lifestyles. Biotrophs feed on living tissue and constitute an economically significant group of pathogens historically. Necrotrophs, which feed on dead tissue, have become economically significant over recent decades, especially those of the Dothideomycetes, which produce necrotrophic ...
Justin D Faris, Timothy L Friesen
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Plant antioxidant gene responses to fungal pathogens
Trends in Microbiology, 1993Antioxidant defense systems are a prominent element in plant responses to environmental stress. Activated oxygen species have themselves been implicated as both a part of the plant's defense against pathogen attack as well as the phytotoxic component of photosensitizing fungal toxins.
J D, Williamson, J G, Scandalios
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Gene targets for fungal and mycotoxin control
Mycotoxin Research, 2006It was initially shown that gallic acid, from hydrolysable tannins in the pelliele of walnut kernels, dramatically inhibits biosynthesis of aflatoxin byAspergillus flavus. The mechanism of this inhibition was found to take place upstream from the gene cluster, including the regulatory gene,aflR, involved in aflatoxin biosynthesis.
J H, Kim +9 more
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Photoregulation of Fungal Gene Expression
1996Photoresponses do not have to be mediated by fresh gene expression. Some responses are so fast that they do not allow enough time for synthesis, maturation, and transport first of the mRNA and then of the polypeptide, and for protein activity. This is the case for phototropism towards blue light, a phenomenon that has been particularly well described ...
Enrique Cerdá-Olmedo +1 more
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Fungal Avirulence Genes: Structure and Possible Functions
Fungal Genetics and Biology, 1998Avirulence (Avr) genes exist in many fungi that share a gene-for-gene relationship with their host plant. They represent unique genetic determinants that prevent fungi from causing disease on plants that possess matching resistance (R) genes. Interaction between elicitors (primary or secondary products of Avr genes) and host receptors in resistant ...
Lauge, R., de Wit, P.J.G.M.
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