Results 71 to 80 of about 186,564 (266)
Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils
Advanced Science, EarlyView.We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr +19 more
wiley +1 more source
Proposal of a new nomenclature for introns in protein-coding genes in fungal mitogenomes
IMA Fungus, 2019 Fungal mitochondrial genes are often invaded by group I or II introns, which represent an ideal marker for understanding fungal evolution. A standard nomenclature of mitochondrial introns is needed to avoid confusion when comparing different fungal ...
Shu Zhang, Yong-Jie Zhang
doaj +1 more source
Engineering Microbial Particles for Next‐Generation Biomedical Platforms
Advanced Science, EarlyView.Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li +7 more
wiley +1 more source
Advanced Science, EarlyView.We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai +8 more
wiley +1 more source
MicrobiomeBackground Increased risk of asthma and other respiratory diseases is associated with exposures to microbial communities growing in damp and moldy indoor environments.
Neeraja Balasubrahmaniam +3 more
doaj +1 more source
Functional analysis of fungal polyketide biosynthesis genes [PDF]
The Journal of Antibiotics, 2010 Fungal polyketides have huge structural diversity from simple aromatics to highly modified complex reduced-type compounds. Despite such diversty, single modular iterative type I polyketide synthases (iPKSs) are responsible for their carbon skeleton construction.
openaire +2 more sources
Advanced Science, EarlyView.ABSTRACT Viruses often hijack host developmental programs to promote infection, but the mechanistic links between reproductive regulation and antiviral immunity remain incompletely understood. Here, we identify a virus‐triggered hierarchical degradation cascade that links antiviral immunity and fertility regulation in rice. We show that the rice grassy
Yuansheng Wu +13 more
wiley +1 more source
BMC Genomics, 2018 Background Caleosin/peroxygenases, CLO/PXG, (designated PF05042 in Pfam) are a group of genes/proteins with anomalous distributions in eukaryotic taxa. We have previously characterised CLO/PXGs in the Viridiplantae.
Farzana Rahman +5 more
doaj +1 more source
Biosynthetic gene clusters and the evolution of fungal chemodiversity
Natural Product Reports, 2020 This highlight synthesizes knowledge of the molecular evolutionary processes – functional divergence, horizontal transfer, andde novoassembly – that govern biosynthetic gene cluster diversification and the generation of chemodiversity in fungi.
Antonis Rokas +4 more
openaire +3 more sources