Results 121 to 130 of about 23,322 (214)

Importance of EMT Factor ZEB1 in cDC1 “MutuDC Line” Mediated Induction of Th1 Immune Response

Frontiers in Immunology, 2018
The role of Epithelial to Mesenchymal Transition (EMT) factor Zeb1 is well defined in metastasis and cancer progression but it's importance in dendritic cells (DCs) is unexplored until now. For the first time we report here that Zeb1 controls immunogenic
Shuchi Smita, Shuchi Smita, Abdul Ahad, Abdul Ahad, Arup Ghosh, Arup Ghosh, Viplov K. Biswas, Viplov K. Biswas, Marianna M. Koga, Bhawna Gupta, Hans Acha-Orbea, Sunil K. Raghav, Sunil K. Raghav, Sunil K. Raghav   +13 more
doaj   +1 more source

Patent Landscape of Helminth Vaccines and Related Technologies [PDF]

, 2013
Executive Summary This report focuses on patent landscape analysis of technologies related to vaccines targeting parasitic worms, also known as helminths.
Burke, Rayna, Cavicchi, Jon R., Kowalski, Stanley P., Michaud-King, Jillian, Schroeder, John   +4 more
core   +1 more source

Ivermectin - old drug, new tricks? [PDF]

, 2017
Ivermectin is one of the most important drugs in veterinary and human medicine for the control of parasitic infection and was the joint focus of the 2015 Nobel Prize in Physiology or Medicine, some 35 years after its remarkable discovery.
Devaney, Eileen, Gillan, Victoria, Laing, Roz   +2 more
core   +1 more source

Genomic investigations of successful invasions: the picture emerging from recent studies

Biological Reviews, Volume 100, Issue 3, Page 1396-1418, June 2025.
ABSTRACT Invasion biology aims to identify traits and mechanisms that contribute to successful invasions, while also providing general insights into the mechanisms underlying population expansion and adaptation to rapid climate and habitat changes. Certain phenotypic attributes have been linked to successful invasions, and the role of genetics has been
Joanna Kołodziejczyk, Anna Fijarczyk, Ilga Porth, Piotr Robakowski, Noel Vella, Adriana Vella, Agnieszka Kloch, Aleksandra Biedrzycka   +7 more
wiley   +1 more source

Machine learning models accurately predict clades of proteocephalidean tapeworms (Onchoproteocephalidea) based on host and biogeographical data

Cladistics, Volume 41, Issue 3, Page 264-282, June 2025.
Abstract Proteocephalids are a cosmopolitan and diverse group of tapeworms (Cestoda) that have colonized vertebrate hosts in freshwater and terrestrial environments. Despite the ubiquity of the group, key macroevolutionary processes that have driven the group's evolution have yet to be identified.
Philippe Vieira Alves, Reinaldo José da Silva, Tomáš Scholz, Alain de Chambrier, José Luis Luque, Anastasiia Duchenko, Daniel Janies, Denis Jacob Machado   +7 more
wiley   +1 more source

Cystatin from the helminth Ascaris lumbricoides upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells

Frontiers in Immunology
BackgroundAscaris lumbricoides cystatin (Al-CPI) prevents the development of allergic airway inflammation and dextran-induced colitis in mice models. It has been suggested that helminth-derived cystatins inhibit cathepsins in dendritic cells (DC), but ...
Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R. Williams, Luis Caraballo   +7 more
doaj   +1 more source

Novel expression of Haemonchus contortus vaccine candidate aminopeptidase H11 using the free-living nematode Caenorhabditis elegans [PDF]

, 2013
With the problem of parasitic nematode drug resistance increasing, vaccine development offers an alternative sustainable control approach. For some parasitic nematodes, native extracts enriched for specific proteins are highly protective.
Antonopoulos, A., Britton, C., Dell, A., Dicker, A.J., Haslam, S.M., Johnston, S.L., Knox, D.P., Mcneilly, T.N., Roberts, B.   +8 more
core   +3 more sources

Type 2 Inflammation and Its Role in Dermatologic Diseases

International Journal of Dermatology, Volume 64, Issue 6, Page 978-991, June 2025.
ABSTRACT Atopic dermatitis, prurigo nodularis, and chronic spontaneous urticaria are immune‐mediated, inflammatory skin conditions characterized by intense itch and disease‐specific skin lesions. Despite their different clinical presentations, the three diseases are unified by an aberrant type 2 immune response involving type 2 cytokines, immune cells,
Raj Chovatiya, Jason E. Hawkes, Douglas DiRuggiero, Leigh Ann Pansch, Elizabeth Simcox, Tayler Gonzalez   +5 more
wiley   +1 more source

Frontiers of parasitology research in the People's Republic of China : infection, diagnosis, protection and surveillance [PDF]

, 2012
: Control and eventual elimination of human parasitic diseases in the People's Republic of China (P.R. China) requires novel approaches, particularly in the areas of diagnostics, mathematical modelling, monitoring, evaluation, surveillance and public ...
Bergquist, R., Chen, J. H., Chen, J. X., Tanner, M., Utzinger, J., Wang, H., Zhou, X. N.   +6 more
core   +2 more sources

Combined TLR2 and TLR4 ligation in the context of bacterial or helminth extracts in human monocyte derived dendritic cells: molecular correlates for Th1/Th2 polarization

BMC Immunology, 2009
Background Recognition of pathogens by dendritic cells (DCs) through interaction with pattern recognition receptors, including Toll like receptors (TLR), is crucial for the initiation of appropriate polarized T helper (Th) cell responses.
van Hellemond Jaap J, Phylipsen Marion, Retra Kim, Everts Bart, van Riet Elly, Tielens Aloysius GM, van der Kleij Desiree, Hartgers Franca C, Yazdanbakhsh Maria   +8 more
doaj   +1 more source