Results 141 to 150 of about 12,335 (183)

Gene manipulation in parasitic helminths

International Journal for Parasitology, 2003
In light of recent growth in available DNA sequence information for a number of parasitic helminths, it is crucial that suitable gene manipulation technologies are developed to facilitate functional genomic studies in these organisms. In this review we discuss recent progress in the development of these technologies in nematode and platyhelminth ...
Jon P, Boyle, Timothy P, Yoshino
openaire   +2 more sources

Helminth genomics: from gene discovery to genome sequencing

Trends in Parasitology, 2002
Abstract A joint meeting of the World Health Organisation-funded Schistosome and Filarial Genome Networks was held at The Institute for Genomic Research (TIGR, Rockville, MD, USA) from 10th to 12th January 2002.
Foster, Jeremy M, Johnston, David A
openaire   +3 more sources

Tubulin-gene Mutation in Drug Resistance in Helminth Parasite: Docking and Molecular Dynamics Simulation Study

Current Chemical Biology, 2023
Background: Drug resistance is an important phenomenon in helminth parasites. Microtubules are among the key chemotherapeutic targets, mutations of which lead to drug resistance. Objectives: The present study investigated the role of F167Y, E198A, and F200Y mutations in β- tubulin protein and their effect on albendazole binding.
Ananta Swargiary, Harmonjit Boro, Dulur Brahma   +2 more
openaire   +1 more source

Prediction of gene expression and codon usage in human parasitic helminths

Genes & Genomics, 2015
Codon usage bias refers to the differences in the occurrence frequency of synonymous codons. To understand the patterns of codon usage in mitochondrial genes we used bioinformatic approaches to analyze the protein coding sequences of W. bancrofti and S. haematobium as no work was reported earlier.
Gulshana A. Mazumder, Arif Uddin, Supriyo Chakraborty   +2 more
openaire   +1 more source

Proteinases and Associated Genes of Parasitic Helminths

1999
Many parasites have deployed proteinases to accomplish some of the tasks imposed by a parasitic life style, including tissue penetration, digestion of host tissue for nutrition and evasion of host immune responses. Information on proteinases from trematodes, cestodes and nematode parasites is reviewed, concentrating on those worms of major medical and ...
J, Tort, P J, Brindley, D, Knox, K H, Wolfe, J P, Dalton   +4 more
openaire   +2 more sources

Digital gene expression analysis of gastrointestinal helminth resistance in Scottish blackface lambs

Molecular Ecology, 2011
AbstractDigital gene expression (DGE) analysis offers a route to gene discovery which by‐passes the need to develop bespoke arrays for nonmodel species, and is therefore a potentially valuable tool for molecular ecologists. Scottish blackface sheep, which vary in resistance to the common abomasal parasitic nematode Teladorsagia circumcincta, were ...
J M, Pemberton, D, Beraldi, B H, Craig, J, Hopkins   +3 more
openaire   +2 more sources

Molecular characterization of genes encoding proteases of helminth parasites

2022
Because of the important contributions of parasites with respect to human morbidity and mortality, and because proteases are implicated in normal and pathological processes, parasite proteases are key biomolecules. Proteases of helminth parasites are essential to the maintenance of parasitism, and adversely affect hosts in a number of ways.
openaire   +2 more sources

Expression of helminth genes in Leishmania: an experimental transfection system to test immunological function

Parasite Immunology, 2008
SUMMARY Functional analysis of genes from parasitic helminths requires, at the present time, heterologous expression. We have adapted the well‐characterized system of transfection in Leishmania protozoal parasites, as a means of analysing the effect of single filarial genes on the mammalian immune system. For example, testing the function of the Brugia
R M, Maizels, N, Gomez-Escobar, L, Prieto-Lafuente, J, Murray, T, Aebischer   +4 more
openaire   +2 more sources

Regulation of HSP70 gene expression during the life cycle of the parasitic helminth Schistosoma mansoni

European Journal of Biochemistry, 1993
Analyses of RNA from different developmental stages of Schistosoma mansoni showed stage‐specific expression of heat‐shock protein 70 (hsp70), which is regulated by a developmental program and by stress. The developmental program, common to hsp70 and other genes (e. g.
S, Neumann, E, Ziv, F, Lantner, I, Schechter   +3 more
openaire   +2 more sources