Results 161 to 170 of about 942 (191)
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Immediate early response genes and cell transformation
Pharmacology & Therapeutics, 2013Cancer has been described as not one disease, but several, each with unique characteristics, symptoms, prognostics and outcomes. Underlying this complexity is a differential expression of genes, leading to a motley of phenotypes which orchestrate the hallmarks of cancer.
Shannon, Healy +2 more
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Calcium regulation of immediate early gene transcription
Journal of Physiology-Paris, 1992Cellular immediate early genes (IEGs) are a class of genes whose transcription is transiently activated within minutes of exposure of cells to a wide range of extracellular stimuli. In mature neurons IEG expression can be triggered by a variety of neutrotransmitters and neurotrophic factors.
M E, Greenberg, M A, Thompson, M, Sheng
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Immediate early gene transcription and synaptic modulation
Journal of Neuroscience Research, 1999Long-term changes in gene expression appear to be critical to the formation of memory, but little is known about its stimulus- transcription coupling. Numerous studies in the last decade, by focusing on unraveling this signal transduction pathway, have investigated the potential role of the immediate-early genes in this process.
M, Walton +6 more
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Light, immediate-early genes, and circadian rhythms
Behavior Genetics, 1996Many diverse behaviors exhibit clear circadian rhythms in their expression. In mammals, these rhythms originate from a neural circadian clock located in the suprachiasmatic nuclei (SCN). Recently, signaling pathways activated by light in the SCN have begun to be identified.
J M, Kornhauser +2 more
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Immediate early gene expression during morphine withdrawal
Neuropharmacology, 1995The expression of immediate early genes (IEG)s c-fos, c-jun and zif/268 was studied during naloxone-precipitated morphine withdrawal in various organs of the rat. Dependence was induced over a period of 6 days by a graded regimen of 6-hourly injections.
Beckmann A.M., Matsumoto I., Wilce P.A.
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Immediate-early genes in nociception
1995Cellular immediate-early genes (IEGs) share a close structural homology with some viral oncogenes. In the eukaryotic genome these counterparts of oncogenes have been termed proto-oncogenes. Recent advances in cellular biology have identified the activation and deactivation of IEGs as molecular mechanisms to control regulated and deregulated growth ...
Tölle, T. +3 more
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2002
Abstract The term immediate early gene (IEG) was borrowed from virology. During the infectious cycle, the viral proteins are expressed in an orderly programme, which involves immediate early, delayed early, and late proteins (Honess and Roizman 1974; Weinheimer and McKnight 1987).
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Abstract The term immediate early gene (IEG) was borrowed from virology. During the infectious cycle, the viral proteins are expressed in an orderly programme, which involves immediate early, delayed early, and late proteins (Honess and Roizman 1974; Weinheimer and McKnight 1987).
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Expression of Immediate Early Genes in Sensory Ganglia
Neurochemical Research, 2001C-Jun and c-Fos belong to the family of immediate early genes. Apart from their role as transcription factors, a basal expression was shown for them in central nervous system tissues. The expression of c-Jun and c-Fos in sensory ganglia of guinea pig, rat and murine sensory ganglia was examined under normal, unstimulated conditions by quantitative ...
Groneberg, David A. +5 more
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Activation of immediate early genes after acute stress
NeuroReport, 1991We used in-situ hybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and ...
S S, Schreiber +3 more
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Kaposi's sarcoma-associated herpesvirus immediate early gene activity
Frontiers in Bioscience, 2004KSHV is the causative agent of three human proliferative disorders: Kaposi s sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Herpesvirus gene expression and viral replication is a complex, tightly regulated process involving latent, immediate early, early, and late viral gene transcription.
Vincent, Lacoste +3 more
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