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Immediate-early genes, neuronal plasticity, and memory
Biochemistry and Cell Biology, 1992The demonstration that the immediate-early gene c-fos is rapidly and transiently expressed in brain following a variety of manipulations has led to intense study of these genes to determine what physiological role they play. The very wide range of stimuli which lead to induction of immediate-early genes (IEGs) in the brain has raised concerns for the ...
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Immediate-early genes induced by antigen receptor stimulation
Current Opinion in Immunology, 1995Immediate early genes induced by triggering of the TCR frequently encode proteins that act in signal transduction cascades. Recent advances concerning several immediate-early proteins have been made, including signal-induced regulation of NF-kappa B by I kappa-B, the role of Nur77 in T-cell selection and apoptosis, and the function of PAC-1 in ...
K, Kelly, U, Siebenlist
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Immediate-early genes, kindling and long-term potentiation
Neuroscience & Biobehavioral Reviews, 1989The mechanism(s) by which long-term changes are induced and maintained in the nervous system are poorly understood. Kindling is an example of a permanent change in brain function that results from repeated elicitation of seizures. Recently, a class of genes called "immediate-early genes" that were previously thought to be only involved in cell division,
M, Dragunow +4 more
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Immediate-early genes and chronic pain
APS Journal, 1994T he hypothesis presented by Zimmerman and Herdegen is an intriguing one. Both clinical and experimental evidence suggest that prolonged nociceptive input or neural injury may produce chronic foci of hyperactivity within the central nervous system (CNS). These foci may be responsible for the development of chronic pain. If this is indeed the case, such
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Immediate-early genes and opioid peptides
1995Cellular stimulation causes the rapid appearance of proteins in the nucleus which function as signal-regulated transcription factors converting membrane events into long-term changes in gene expression. These transcription factors are the products of a variety of immediate early genes (IEG).
J. Kraus, B. Bacher, X. Wang, V. Höllt
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Activation of immediate early genes and memory formation
Cellular and Molecular Life Sciences (CMLS), 1999Long-term plastic changes in the brain, including those supporting memory formation, are assumed to depend on permanent functional alterations in neuronal cells that require reprogramming of gene expression. Inducible transcription factors encoded by immediate early genes such as c-fos, c-jun, jun-B and zif/268 (also known as krox-24, egr-1, TIS 8 ...
W, Tischmeyer, R, Grimm
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Immediate-early gene expression in the barrel cortex
Somatosensory & Motor Research, 2006Since their detection in the early 1980s immediate-early genes (most of them being inducible transcription factors) have been regarded as molecular keys to the orchestration of late-effector genes that ultimately would enable functional and structural adaptation of the brain to changing external and internal demands.
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Immediate-early genes: ten years on
Trends in Neurosciences, 1995J I, Morgan, T, Curran
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