Results 181 to 190 of about 5,788,302 (308)

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development.

Cell, 1993
A. Ehlich, S. Schaal, H. Gu, D. Kitamura, Werner Müller, K. Rajewsky   +5 more
semanticscholar   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

In-silico pharmacological insights into the therapeutic potential of microRNAs for microplastic-associated cancers. [PDF]

Front Cell Dev Biol
Baspakova A, Zare A, Mussin NM, Tanideh N, Zhilisbayeva KR, Safarzoda Sharoffidin R, Suleimenova R, Yelgondina G, Kaliyeva AE, Umbetova AA, Zinaliyeva A, Tamadon A.   +11 more
europepmc   +1 more source

Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.

Proceedings of the National Academy of Sciences of the United States of America, 1984
T. Parslow, D. Blair, W. Murphy, D. Granner   +3 more
semanticscholar   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Distinct pulmonary pathophysiological mechanisms in COPD, bronchiectasis, and primary immunodeficiency: a multi-omics investigation of disease heterogeneity via sputum and blood profiling. [PDF]

Respir Res
Graeter S, Gonzalez-Jaramillo N, Wildschut MHE, Capriotti L, Saxenhofer M, Robador JR, Monaghan K, Woodman N, Field J, Wilson N, Rees M, Hauswald M, Roca CP, Feussner A, Schulze I, Stewart A, Schaub A, Chan S, Douglass JA, Schnell A.   +19 more
europepmc   +1 more source

Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL).

Blood, 2003
R. Abraham, S. Geyer, T. Price-Troska, C. Allmer, R. Kyle, M. Gertz, R. Fonseca   +6 more
semanticscholar   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Gene Profiling Analyses of Synovium Tissues in Korean Osteoarthritis Patients. [PDF]

In Vivo
Roh J, Jeon J, Jo S, Park G, Kang J, Moon SW, Kim W.   +6 more
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source